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    NfI Nuclear factor I [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43782, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NfIprovided by FlyBase
    Official Full Name
    Nuclear factor Iprovided by FlyBase
    Primary source
    FLYBASE:FBgn0042696
    Locus tag
    Dmel_CG2380
    See related
    AllianceGenome:FB:FBgn0042696
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2380; Dmel\CG2380; NFI
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in dorsal pharyngeal muscle cell; embryonic dorsal epidermis; embryonic ventral epidermis; larval muscle system; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in Marshall-Smith syndrome; NFIA-related disorder; and Sotos syndrome 2. Orthologous to several human genes including NFIC (nuclear factor I C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See NfI in Genome Data Viewer
    Location:
    102B1-102B2; 4-0 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (268175..276369, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (288801..296995, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene defective proboscis extension response 7 Neighboring gene Rho GTPase activating protein at 102A Neighboring gene long non-coding RNA:CR44023 Neighboring gene Synaptotagmin 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits. Reyes-Ortiz AM, et al. iScience, 2023 Jan 20. PMID 36590162, Free PMC Article
    2. Roles of the NFI/CTF gene family in transcription and development. Gronostajski RM. Gene, 2000 May 16. PMID 10831836
    3. The Nuclear Factor I (NFI) gene family in mammary gland development and function. Murtagh J, et al. J Mammary Gland Biol Neoplasia, 2003 Apr. PMID 14635798
    4. Recurrent NFIA K125E substitution represents a loss-of-function allele: Sensitive in vitro and in vivo assays for nontruncating alleles. Uehara T, et al. Am J Med Genet A, 2021 Jul. PMID 33973697, Free PMC Article
    5. The KRÜPPEL-like transcription factor DATILÓGRAFO is required in specific cholinergic neurons for sexual receptivity in Drosophila females. Schinaman JM, et al. PLoS Biol, 2014 Oct. PMID 25291190, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Recurrent NFIA K125E substitution represents a loss-of-function allele: Sensitive in vitro and in vivo assays for nontruncating alleles.
      Title: Recurrent NFIA K125E substitution represents a loss-of-function allele: Sensitive in vitro and in vivo assays for nontruncating alleles.
    2. The drosophila NfI gene structure is discussed in this paper in relation to the structures of other metazoan NFI genes.
      Title: The Nuclear Factor I (NFI) gene family in mammary gland development and function.
    3. The initial description of the Drosophila NfI gene and conserved intron positions relative to the C. elegans nfi-1 gene and vertebrate NFI genes are discussed in this paper.
      Title: Roles of the NFI/CTF gene family in transcription and development.
    4. Evidence of conserved intron locations within DNA-binding domain of Drosophila, C. elegans and Ciona NFI genes
      Title: The Nuclear Factor I (NFI) gene family in mammary gland development and function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c270135-269973 mobile_element_type = transposon:INE-1{}5322
    • Loc: c272913-272866 mobile_element_type = transposon:INE-1{}5323

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear factor I
    Names
    CG2380-PB
    CG2380-PC
    NfI-PB
    NfI-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      268175..276369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272122.2 → NP_001259051.1  nuclear factor I, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259051.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L0MPW8
      Conserved Domains (2) summary
      cl00055
      Location:85 → 193
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam10524
      Location:25 → 64
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

    2. NM_205870.3 → NP_995592.2  nuclear factor I, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995592.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KQN8, Q86P06
      Conserved Domains (2) summary
      cl00055
      Location:85 → 193
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam10524
      Location:25 → 64
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    L0MPW8 L0MPW8
    Q86P06 Q86P06

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