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    cmb combover [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39513, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cmbprovided by FlyBase
    Official Full Name
    comboverprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036365
    Locus tag
    Dmel_CG10732
    See related
    AllianceGenome:FB:FBgn0036365
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10732; Cmb; Dmel\CG10732; NEST:bs28e06
    Summary
    Involved in imaginal disc-derived wing hair organization and sperm individualization. Is expressed in several structures, including adult head; anterior endoderm; ganglia; larval somatic muscle cell; and mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cmb in Genome Data Viewer
    Location:
    70B1-70B1; 3-40 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13442594..13449245)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13435694..13442345)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Jumonji domain containing 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Detecting New Allies: Modifier Screen Identifies a Genetic Interaction Between Imaginal disc growth factor 3 and combover, a Rho-kinase Substrate, During Dorsal Appendage Tube Formation in Drosophila. Espinoza CY, et al. G3 (Bethesda), 2020 Oct 5. PMID 32855169, Free PMC Article
    2. Combover/CG10732, a novel PCP effector for Drosophila wing hair formation. Fagan JK, et al. PLoS One, 2014. PMID 25207969, Free PMC Article
    3. Combover interacts with the axonemal component Rsp3 and is required for Drosophila sperm individualization. Steinhauer J, et al. Development, 2019 Sep 2. PMID 31391193, Free PMC Article
    4. Expression profiling of a hypercontraction-induced myopathy in Drosophila suggests a compensatory cytoskeletal remodeling response. Montana ES, et al. J Biol Chem, 2006 Mar 24. PMID 16415344
    5. Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. Lowe N, et al. Development, 2014 Oct. PMID 25294943, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in imaginal disc-derived wing hair organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    combover
    Names
    CG10732-PA
    CG10732-PB
    CG10732-PC
    CG10732-PD
    cmb-PA
    cmb-PB
    cmb-PC
    cmb-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13442594..13449245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168546.3 → NP_729901.1  combover, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729901.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VU76
      Related
      FBpp0075586
      Conserved Domains (1) summary
      COG1196
      Location:339 → 720
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_001274872.1 → NP_001261801.1  combover, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261801.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFI2
      Conserved Domains (1) summary
      COG1196
      Location:339 → 720
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. NM_001274873.1 → NP_001261802.1  combover, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261802.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFE5
      Conserved Domains (1) summary
      COG1196
      Location:339 → 720
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. NM_140393.4 → NP_648650.1  combover, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648650.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961X4
      Related
      FBpp0075587
      Conserved Domains (1) summary
      COG1196
      Location:61 → 442
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFE5 M9PFE5
    M9PFI2 M9PFI2
    Q961X4 Q961X4
    Q9VU76 Q9VU76

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