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    dop drop out [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39686, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dopprovided by FlyBase
    Official Full Name
    drop outprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267390
    Locus tag
    Dmel_CG6498
    See related
    AllianceGenome:FB:FBgn0267390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6498; Dmel\CG6498; MAST 205; MAST205
    Summary
    Enables protein kinase activity. Involved in several processes, including border follicle cell migration; dosage compensation by hyperactivation of X chromosome; and lipid droplet transport along microtubule. Located in cytoplasm. Is expressed in adult head; anterior midgut primordium; organism; posterior midgut primordium; and spermatozoon. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 108; female breast cancer; and mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations. Orthologous to several human genes including MAST1 (microtubule associated serine/threonine kinase 1); MAST2 (microtubule associated serine/threonine kinase 2); and MAST3 (microtubule associated serine/threonine kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dop in Genome Data Viewer
    Location:
    71E1-71E1; 3-43 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15566013..15576313)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15559113..15569413)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Argonaute 2 Neighboring gene uncharacterized protein Neighboring gene Squamous cell carcinoma-related oncogene Neighboring gene UFM1 specific peptidase 2 Neighboring gene marionette

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drop out: a third chromosome maternal-effect locus required for formation of the Drosophila cellular blastoderm. Galewsky S, et al. Mol Reprod Dev, 1992 Aug. PMID 1497881
    2. Natural variation of the amino-terminal glutamine-rich domain in Drosophila argonaute2 is not associated with developmental defects. Hain D, et al. PLoS One, 2010 Dec 17. PMID 21253006, Free PMC Article
    3. Atypical cadherin, Fat2, regulates axon terminal organization in the developing Drosophila olfactory receptor neurons. Vien KM, et al. iScience, 2024 Jul 19. PMID 39055932, Free PMC Article
    4. The endogenous siRNA pathway is involved in heterochromatin formation in Drosophila. Fagegaltier D, et al. Proc Natl Acad Sci U S A, 2009 Dec 15. PMID 19948966, Free PMC Article
    5. The Drosophila MAST kinase Drop out is required to initiate membrane compartmentalisation during cellularisation and regulates dynein-based transport. Hain D, et al. Development, 2014 May. PMID 24803657, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellularization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dosage compensation by hyperactivation of X chromosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid droplet transport along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell size IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    drop out
    Names
    CG6498-PA
    CG6498-PB
    dop-PA
    dop-PB
    NP_001261884.1
    NP_648778.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15566013..15576313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274955.1 → NP_001261884.1  drop out, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261884.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUQ9
      Conserved Domains (4) summary
      smart00220
      Location:835 → 1110
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:1506 → 1587
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:834 → 1115
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:344 → 702
      DUF1908; Domain of unknown function (DUF1908)

    2. NM_140521.3 → NP_648778.1  drop out, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648778.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUQ9
      Related
      FBpp0075315
      Conserved Domains (4) summary
      smart00220
      Location:835 → 1110
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:1506 → 1587
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:834 → 1115
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:344 → 702
      DUF1908; Domain of unknown function (DUF1908)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSY6 Q8MSY6
    Q9VUQ9 Q9VUQ9

    Gene LinkOut

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