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    CG4678 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32652, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4678provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030778
    Locus tag
    Dmel_CG4678
    See related
    AllianceGenome:FB:FBgn0030778
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4678
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to be active in extracellular space. Is expressed in several structures, including adult head; embryonic anal pad; embryonic hypopharynx; embryonic precursor of adult foregut; and gut section. Orthologous to human CPM (carboxypeptidase M). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4678 in Genome Data Viewer
    Location:
    15A1-15A3; 1-55 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16696131..16711145)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16590164..16605178)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene singles bar Neighboring gene Abnormal X segregation Neighboring gene Septin 4 Neighboring gene uncharacterized protein Neighboring gene spheroide Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduction in mutation frequency by very low-dose gamma irradiation of Drosophila melanogaster germ cells. Ogura K, et al. Radiat Res, 2009 Jan. PMID 19138046
    2. Functional variants identify sex-specific genes and pathways in Alzheimer's Disease. Bourquard T, et al. Nat Commun, 2023 May 13. PMID 37179358, Free PMC Article
    3. The genomic response to courtship song stimulation in female Drosophila melanogaster. Immonen E, et al. Proc Biol Sci, 2012 Apr 7. PMID 21976688, Free PMC Article
    4. X-chromosome-wide profiling of MSL-1 distribution and dosage compensation in Drosophila. Legube G, et al. Genes Dev, 2006 Apr 1. PMID 16547175, Free PMC Article
    5. The Insect Prothoracic Gland as a Model for Steroid Hormone Biosynthesis and Regulation. Ou Q, et al. Cell Rep, 2016 Jun 28. PMID 27320926, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4678-PD
    CG4678-PE
    CG4678-PF
    CG4678-PG
    CG4678-PI
    CG4678-PJ
    CG4678-PK
    CG4678-PL
    NP_001033850.2
    NP_001138210.1
    • unusual splice
    NP_001138211.1
    • unusual splice
    NP_001245718.1
    NP_001285344.1
    NP_001285345.1
    NP_573152.2
    • unusual splice
    NP_728012.2
    • unusual splice

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16696131..16711145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144738.2 → NP_001138210.1  uncharacterized protein Dmel_CG4678, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138210.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0Z6, G4LU56, G4LU72
      Conserved Domains (2) summary
      cd03858
      Location:72 → 368
      M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
      cd11308
      Location:372 → 446
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

    2. NM_001144739.2 → NP_001138211.1  uncharacterized protein Dmel_CG4678, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138211.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0Z5, G4LU56
      Conserved Domains (2) summary
      cd03858
      Location:72 → 377
      M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
      cd11308
      Location:381 → 455
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

    3. NM_001298415.1 → NP_001285344.1  uncharacterized protein Dmel_CG4678, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285344.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4LU56, X2JFS7
      Conserved Domains (2) summary
      cd03858
      Location:72 → 373
      M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
      cd11308
      Location:377 → 451
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

    4. NM_001038761.2 → NP_001033850.2  uncharacterized protein Dmel_CG4678, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033850.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023GPN7, G4LU56
      Conserved Domains (2) summary
      cd03858
      Location:72 → 363
      M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
      cd11308
      Location:367 → 441
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

    5. NM_001258789.2 → NP_001245718.1  uncharacterized protein Dmel_CG4678, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245718.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4LU56, M9NFA0
      Conserved Domains (2) summary
      cd03858
      Location:72 → 363
      M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
      cd11308
      Location:367 → 441
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

    6. NM_001298416.1 → NP_001285345.1  uncharacterized protein Dmel_CG4678, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285345.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JC90
      Conserved Domains (2) summary
      cd03858
      Location:1 → 254
      M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
      cd11308
      Location:258 → 332
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

    7. NM_167536.4 → NP_728012.2  uncharacterized protein Dmel_CG4678, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728012.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4N7, G4LU56
      Conserved Domains (2) summary
      cd03858
      Location:72 → 377
      M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
      cd11308
      Location:381 → 455
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

    8. NM_132924.4 → NP_573152.2  uncharacterized protein Dmel_CG4678, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573152.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4LU56, Q9VXC4
      Conserved Domains (2) summary
      cd03858
      Location:72 → 368
      M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
      cd11308
      Location:372 → 446
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A023GPN7 A0A023GPN7
    A4V4N7 A4V4N7
    B7Z0Z5 B7Z0Z5
    B7Z0Z6 B7Z0Z6
    M9NFA0 M9NFA0
    Q8MRP2 Q8MRP2
    Q9VXC4 Q9VXC4
    X2JC90 X2JC90
    X2JFS7 X2JFS7

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