Mpi Mannose phosphate isomerase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mpiprovided by FlyBase
Official Full Name: Mannose phosphate isomeraseprovided by FlyBase
Primary source: FLYBASE:FBgn0286506
Locus tag: Dmel_CG8417
See related: AllianceGenome:FB:FBgn0286506
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8417; Dmel\CG8417; dMPI; MPI
Summary: Predicted to enable mannose-6-phosphate isomerase activity. Predicted to be involved in GDP-mannose biosynthetic process from fructose-6-phosphate and mannose to fructose-6-phosphate catabolic process. Predicted to be active in cytosol. Is expressed in adult head. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and congenital disorder of glycosylation Ib. Orthologous to human MPI (mannose phosphate isomerase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (9759622..9761208)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (5585344..5586930)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables mannose-6-phosphate isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mannose-6-phosphate isomerase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GDP-mannose biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GDP-mannose biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GDP-mannose biosynthetic process from fructose-6-phosphate	ISS Inferred from Sequence or Structural Similarity more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in mannose to fructose-6-phosphate catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

NP_649940.1

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The following sections contain reference sequences that belong to a specific genome build. Explain