U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Nepl5 Neprilysin-like 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33892, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Nepl5provided by FlyBase
    Official Full Name
    Neprilysin-like 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0031808
    Locus tag
    Dmel_CG9507
    See related
    AllianceGenome:FB:FBgn0031808
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9507; Dmel\CG9507
    Summary
    Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Nepl5 in Genome Data Viewer
    Location:
    26C4-26C4; 2-19 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6381266..6383419)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6381266..6383419)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Neprilysin-like 4 Neighboring gene slow as molasses Neighboring gene Dpr-interacting protein epsilon Neighboring gene Neprilysin-like 6 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Function and dynamics of slam in furrow formation in early Drosophila embryo. Acharya S, et al. Dev Biol, 2014 Feb 15. PMID 24368071
    2. Slow as molasses is required for polarized membrane growth and germ cell migration in Drosophila. Stein JA, et al. Development, 2002 Aug. PMID 12135929
    3. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
    4. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
    5. Prevalence of off-target effects in Drosophila RNA interference screens. Ma Y, et al. Nature, 2006 Sep 21. PMID 16964239

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Neprilysin-like 5
    Names
    CG9507-PA
    Nepl5-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6381266..6383419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135178.3 → NP_609022.1  Neprilysin-like 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609022.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VME3, T1W2R4
      Related
      FBpp0078885
      Conserved Domains (2) summary
      COG3590
      Location:42 → 684
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
      cl14813
      Location:48 → 682
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGB8 Q8IGB8
    Q95U11 Q95U11
    Q9VME3 Q9VME3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous