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    Pfrx 6-phosphofructo-2-kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32938, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pfrxprovided by FlyBase
    Official Full Name
    6-phosphofructo-2-kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027621
    Locus tag
    Dmel_CG3400
    See related
    AllianceGenome:FB:FBgn0027621
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3400; Dmel\CG3400; pfk2; Pfk2; PFK2
    Summary
    Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in several processes, including carbohydrate phosphorylation; fructose 2,6-bisphosphate metabolic process; and positive regulation of glycolytic process through fructose-6-phosphate. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including adult head; anlage in statu nascendi; cuboidal/columnar epithelium; embryonic/larval midgut primordium; and mesoderm. Orthologous to several human genes including PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2) and PFKFB4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pfrx in Genome Data Viewer
    Location:
    18C8-18C8; 1-62 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19495505..19509350)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19389538..19403383)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44340 Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) 18 kDa subunit Neighboring gene uncharacterized protein Neighboring gene kish Neighboring gene Isocitrate dehydrogenase 3a Neighboring gene CoRest

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    mobile_element

    • Loc: 19502475-19502972 mobile_element_type = transposon:FB{}5617

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 6-phosphofructo-2-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 6-phosphofructo-2-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 6-phosphofructo-2-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables fructose-2,6-bisphosphate 2-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fructose-2,6-bisphosphate 2-phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in carbohydrate phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fructose 2,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fructose 2,6-bisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fructose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of glycolytic process through fructose-6-phosphate ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    6-phosphofructo-2-kinase
    Names
    CG3400-PA
    CG3400-PB
    CG3400-PD
    CG3400-PE
    CG3400-PF
    CG3400-PG
    CG3400-PH
    CG3400-PI
    CG3400-PJ
    CG3400-PK
    CG3400-PL
    CG3400-PM
    CG3400-PN
    Pfrx-PA
    Pfrx-PB
    Pfrx-PD
    Pfrx-PE
    Pfrx-PF
    Pfrx-PG
    Pfrx-PH
    Pfrx-PI
    Pfrx-PJ
    Pfrx-PK
    Pfrx-PL
    Pfrx-PM
    Pfrx-PN
    fi-phosphofructo-2-kinase
    fructose 2,6 bisphosphatase
    phosphofructokinase
    NP_001245750.1
    NP_001245751.1
    NP_001245752.1
    NP_001285440.1
    NP_001285441.1
    NP_477451.1
    NP_477452.3
    NP_728249.1
    NP_728250.1
    NP_728251.1
    NP_728252.1
    NP_728253.1
    NP_728254.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19495505..19509350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167654.2NP_728252.1  6-phosphofructo-2-kinase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728252.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL9, Q0KHQ6
      Related
      FBpp0074482
      Conserved Domains (2) summary
      pfam00300
      Location:288471
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:74285
      6PF2K; 6-phosphofructo-2-kinase
    2. NM_001258821.2NP_001245750.1  6-phosphofructo-2-kinase, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245750.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL9, Q0KHQ6
      Conserved Domains (2) summary
      pfam00300
      Location:288471
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:74285
      6PF2K; 6-phosphofructo-2-kinase
    3. NM_167651.2NP_728249.1  6-phosphofructo-2-kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728249.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL9, Q0KHQ6
      Related
      FBpp0074483
      Conserved Domains (2) summary
      pfam00300
      Location:288471
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:74285
      6PF2K; 6-phosphofructo-2-kinase
    4. NM_167656.2NP_728254.1  6-phosphofructo-2-kinase, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728254.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL9, Q0KHQ6
      Related
      FBpp0074484
      Conserved Domains (2) summary
      pfam00300
      Location:288471
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:74285
      6PF2K; 6-phosphofructo-2-kinase
    5. NM_058104.5NP_477452.3  6-phosphofructo-2-kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477452.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWH7, Q9Y1W2
      Related
      FBpp0074486
      Conserved Domains (3) summary
      pfam00300
      Location:468651
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:254465
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:256412
      AAA_33; AAA domain
    6. NM_001298512.1NP_001285441.1  6-phosphofructo-2-kinase, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285441.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JED9
      Conserved Domains (3) summary
      pfam00300
      Location:467650
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:253464
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:255411
      AAA_33; AAA domain
    7. NM_058103.3NP_477451.1  6-phosphofructo-2-kinase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477451.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWH7, Q9Y1W2
      Related
      FBpp0074485
      Conserved Domains (3) summary
      pfam00300
      Location:468651
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:254465
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:256412
      AAA_33; AAA domain
    8. NM_167652.2NP_728250.1  6-phosphofructo-2-kinase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728250.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL9, Q0KHQ6
      Related
      FBpp0074488
      Conserved Domains (2) summary
      pfam00300
      Location:288471
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:74285
      6PF2K; 6-phosphofructo-2-kinase
    9. NM_167655.2NP_728253.1  6-phosphofructo-2-kinase, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728253.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL9, Q0KHQ6
      Related
      FBpp0074487
      Conserved Domains (2) summary
      pfam00300
      Location:288471
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:74285
      6PF2K; 6-phosphofructo-2-kinase
    10. NM_001258822.2NP_001245751.1  6-phosphofructo-2-kinase, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245751.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL9, Q0KHQ6
      Conserved Domains (2) summary
      pfam00300
      Location:288471
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:74285
      6PF2K; 6-phosphofructo-2-kinase
    11. NM_001258823.2NP_001245752.1  6-phosphofructo-2-kinase, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245752.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL9, Q0KHQ6
      Conserved Domains (2) summary
      pfam00300
      Location:288471
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:74285
      6PF2K; 6-phosphofructo-2-kinase
    12. NM_167653.3NP_728251.1  6-phosphofructo-2-kinase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728251.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL9, Q0KHQ6
      Related
      FBpp0074489
      Conserved Domains (2) summary
      pfam00300
      Location:288471
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:74285
      6PF2K; 6-phosphofructo-2-kinase
    13. NM_001298511.1NP_001285440.1  6-phosphofructo-2-kinase, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285440.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL9, Q0KHQ6
      Conserved Domains (2) summary
      pfam00300
      Location:288471
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:74285
      6PF2K; 6-phosphofructo-2-kinase