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    Pask PAS kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37824, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Paskprovided by FlyBase
    Official Full Name
    PAS kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034950
    Locus tag
    Dmel_CG3105
    See related
    AllianceGenome:FB:FBgn0034950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3105; Dmel\CG3105; pask
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and negative regulation of glycogen biosynthetic process. Predicted to be active in cytosol and nucleus. Is expressed in adult brain; adult mushroom body; embryonic brain; larval ventral nerve cord; and organism. Orthologous to human PASK (PAS domain containing serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pask in Genome Data Viewer
    Location:
    60A16-60B1; 2-106 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23988738..23992049)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19876261..19879572)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Sox box protein 14 Neighboring gene uncharacterized protein Neighboring gene Peptidylglycine-alpha-hydroxylating monooxygenase Neighboring gene mir-1009 stem loop Neighboring gene uncharacterized protein Neighboring gene Obscurin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Strategies for gene disruption in Drosophila. Lin SC, et al. Cell Biosci, 2014. PMID 25364499, Free PMC Article
    2. PHM is required for normal developmental transitions and for biosynthesis of secretory peptides in Drosophila. Jiang N, et al. Dev Biol, 2000 Oct 1. PMID 10993678
    3. Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases. Beumer KJ, et al. Proc Natl Acad Sci U S A, 2008 Dec 16. PMID 19064913, Free PMC Article
    4. The Drosophila basic helix-loop-helix protein DIMMED directly activates PHM, a gene encoding a neuropeptide-amidating enzyme. Park D, et al. Mol Cell Biol, 2008 Jan. PMID 17967878, Free PMC Article
    5. Ebi alleviates excessive growth signaling through multiple epigenetic functions in Drosophila. Lim YM, et al. Genes Cells, 2013 Nov. PMID 23919509

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    PAS kinase
    Names
    CG3105-PA
    Pask-PA
    NP_611864.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23988738..23992049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138020.3 → NP_611864.1  PAS kinase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611864.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SH0, Q9W1E0
      Related
      FBpp0072069
      Conserved Domains (4) summary
      smart00220
      Location:576 → 828
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00130
      Location:74 → 169
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      cd14004
      Location:575 → 828
      STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
      pfam13426
      Location:74 → 169
      PAS_9; PAS domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95SH0 Q95SH0

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