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    elg1 enhanced level of genomic instability 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39770, updated on 9-Dec-2024

    Summary

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    Official Symbol
    elg1provided by FlyBase
    Official Full Name
    enhanced level of genomic instability 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0036574
    Locus tag
    Dmel_CG16838
    See related
    AllianceGenome:FB:FBgn0036574
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16838; Dmel\CG16838; Elg1
    Summary
    Predicted to enable DNA binding activity and DNA clamp unloader activity. Involved in oogenesis. Part of Elg1 RFC-like complex. Orthologous to human ATAD5 (ATPase family AAA domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See elg1 in Genome Data Viewer
    Location:
    72D9-72D9; 3-44 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16132028..16136691)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16125128..16129791)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Signal sequence receptor beta Neighboring gene TRAPP subunit 20 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional regulation of the Drosophila rfc1 gene by the DRE-DREF pathway. Tsuchiya A, et al. FEBS J, 2007 Apr. PMID 17381512
    2. The Enok acetyltransferase complex interacts with Elg1 and negatively regulates PCNA unloading to promote the G1/S transition. Huang F, et al. Genes Dev, 2016 May 15. PMID 27198229, Free PMC Article
    3. Whole transcriptome screening for novel genes involved in meiosis and fertility in Drosophila melanogaster. Sun S, et al. Sci Rep, 2024 Feb 13. PMID 38351116, Free PMC Article
    4. Bivalent complexes of PRC1 with orthologs of BRD4 and MOZ/MORF target developmental genes in Drosophila. Kang H, et al. Genes Dev, 2017 Oct 1. PMID 29070704, Free PMC Article
    5. A genetic screen based on in vivo RNA imaging reveals centrosome-independent mechanisms for localizing gurken transcripts in Drosophila. Hayashi R, et al. G3 (Bethesda), 2014 Apr 16. PMID 24531791, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA clamp unloader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Elg1 RFC-like complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    enhanced level of genomic instability 1
    Names
    CG16838-PC
    CG16838-PD
    CG16838-PE
    elg1 homolog
    elg1-PC
    elg1-PD
    elg1-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16132028..16136691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206381.1 → NP_996103.1  enhanced level of genomic instability 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996103.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86BP6, Q8MSZ2, Q9VUZ2
      Conserved Domains (2) summary
      pfam06936
      Location:57 → 129
      Selenoprotein_S; Selenoprotein S (SelS)
      cl21455
      Location:699 → 828
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001259860.2 → NP_001246789.1  enhanced level of genomic instability 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246789.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUZ2
      Conserved Domains (2) summary
      pfam06936
      Location:1 → 73
      Selenoprotein_S; Selenoprotein S (SelS)
      cl21455
      Location:643 → 772
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_206380.2 → NP_996102.1  enhanced level of genomic instability 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996102.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUZ2
      Conserved Domains (2) summary
      pfam06936
      Location:1 → 73
      Selenoprotein_S; Selenoprotein S (SelS)
      cl21455
      Location:643 → 772
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86BP6.1 Q86BP6

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