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    Meics Meiotic central spindle [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39539, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Meicsprovided by FlyBase
    Official Full Name
    Meiotic central spindleprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025874
    Locus tag
    Dmel_CG8474
    See related
    AllianceGenome:FB:FBgn0025874
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8474; Dmel\CG8474
    Summary
    Predicted to enable zinc ion binding activity. Located in cytoplasm; nucleus; and spindle microtubule. Is expressed in dorsal pharyngeal muscle cell; head mesoderm; larval muscle system; organism; and trunk mesoderm. Orthologous to human ZNF254 (zinc finger protein 254); ZNF726 (zinc finger protein 726); and ZNF93 (zinc finger protein 93). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Meics in Genome Data Viewer
    Location:
    70C7-70C7; 3-41 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13962658..13964702, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13955758..13957802, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Dynactin 1, p150 subunit Neighboring gene uncharacterized protein Neighboring gene short spindle 2 Neighboring gene Nuclear export factor 3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Meics, a novel zinc-finger protein which relocates from nuclei to the central meiotic spindle during Drosophila spermatogenesis. Panzera Y, et al. Mech Dev, 2001 Aug. PMID 11472846
    2. The microtubule catastrophe promoter Sentin delays stable kinetochore-microtubule attachment in oocytes. Głuszek AA, et al. J Cell Biol, 2015 Dec 21. PMID 26668329, Free PMC Article
    3. Toward a physical map of Drosophila buzzatii. Use of randomly amplified polymorphic dna polymorphisms and sequence-tagged site landmarks. Laayouni H, et al. Genetics, 2000 Dec. PMID 11102375, Free PMC Article
    4. Sox21b underlies the rapid diversification of a novel male genital structure between Drosophila species. Ridgway AM, et al. Curr Biol, 2024 Mar 11. PMID 38309269
    5. Prevalence of off-target effects in Drosophila RNA interference screens. Ma Y, et al. Nature, 2006 Sep 21. PMID 16964239

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    meiotic central spindle
    Names
    CG8474-PA
    CG8474-PB
    Meics-PA
    Meics-PB
    zinc-finger-motif-protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13962658..13964702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274886.1 → NP_001261815.1  meiotic central spindle, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261815.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF60
      Conserved Domains (6) summary
      COG5048
      Location:383 → 571
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:402 → 422
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:520 → 540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:400 → 422
      zf-C2H2; Zinc finger, C2H2 type
      pfam07776
      Location:21 → 95
      zf-AD; Zinc-finger associated domain (zf-AD)
      pfam13465
      Location:442 → 466
      zf-H2C2_2; Zinc-finger double domain

    2. NM_079338.3 → NP_524062.1  meiotic central spindle, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524062.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96395, Q9VUA4
      Related
      FBpp0075533
      Conserved Domains (6) summary
      COG5048
      Location:395 → 583
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:414 → 434
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:532 → 552
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:412 → 434
      zf-C2H2; Zinc finger, C2H2 type
      pfam07776
      Location:21 → 95
      zf-AD; Zinc-finger associated domain (zf-AD)
      pfam13465
      Location:454 → 478
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PF60 M9PF60
    O96395 O96395

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