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    Crk Crk oncogene [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43775, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Crkprovided by FlyBase
    Official Full Name
    Crk oncogeneprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024811
    Locus tag
    Dmel_CG1587
    See related
    AllianceGenome:FB:FBgn0024811
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CED-2; CG1587; crk; CRK; D-Crk; D-CRK; dCrk; dCRK; Dcrk; DCrk; Dmel\CG1587
    Summary
    Enables receptor tyrosine kinase binding activity. Involved in several processes, including border follicle cell migration; imaginal disc fusion, thorax closure; and positive regulation of JNK cascade. Predicted to be active in cytoplasm. Is expressed in several structures, including cephalic furrow; gut section; larval ventral nerve cord; somatic mesoderm; and visceral muscle cell. Human ortholog(s) of this gene implicated in chronic myeloid leukemia. Orthologous to human CRKL (CRK like proto-oncogene, adaptor protein) and CRK (CRK proto-oncogene, adaptor protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Crk in Genome Data Viewer
    Location:
    102A8-102A8; 4-0 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (210224..213165)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (230850..233791)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44441 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene antisense RNA:CR46065 Neighboring gene yellow-h

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a Drosophila homologue to vertebrate Crk by interaction with MBC. Galletta BJ, et al. Gene, 1999 Mar 4. PMID 10072777
    2. The CDM superfamily protein MBC directs myoblast fusion through a mechanism that requires phosphatidylinositol 3,4,5-triphosphate binding but is independent of direct interaction with DCrk. Balagopalan L, et al. Mol Cell Biol, 2006 Dec. PMID 17030600, Free PMC Article
    3. A pipeline for precise and efficient genome editing by sgRNA-Cas9 RNPs in Drosophila. Nyberg KG, et al. Fly (Austin), 2020 Mar-Dec. PMID 33016195, Free PMC Article
    4. p120 Ras GTPase-activating protein associates with fibroblast growth factor receptors in Drosophila. Woodcock SA, et al. Biochem J, 2004 Jun 15. PMID 15030317, Free PMC Article
    5. Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy. Ziegenfuss JS, et al. Nat Neurosci, 2012 Jun 17. PMID 22706267, Free PMC Article

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 211070-211123 mobile_element_type = transposon:INE-1{}4847

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in enzyme-linked receptor protein signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ephrin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in imaginal disc fusion, thorax closure IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in myoblast fusion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in phagocytosis, engulfment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Crk oncogene
    Names
    CG1587-PA
    CG1587-PB
    CG1587-PC
    CG1587-PD
    CG1587-PE
    CG1587-PG
    CG1587-PH
    Crk-PA
    Crk-PB
    Crk-PC
    Crk-PD
    Crk-PE
    Crk-PG
    Crk-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      210224..213165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258483.2 → NP_001245412.1  Crk oncogene, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245412.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9XVM7
      Conserved Domains (2) summary
      cd09926
      Location:4 → 108
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
      cd11758
      Location:109 → 163
      SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

    2. NM_143651.6 → NP_651908.1  Crk oncogene, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651908.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53XD2, Q9XYM0
      Related
      FBpp0088182
      Conserved Domains (3) summary
      cd09926
      Location:4 → 108
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
      cd11758
      Location:109 → 163
      SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
      cd11759
      Location:201 → 257
      SH3_CRK_C; C-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

    3. NM_001297781.1 → NP_001284710.1  Crk oncogene, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284710.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JCS2
      Conserved Domains (1) summary
      cl15255
      Location:4 → 52
      SH2; Src homology 2 (SH2) domain

    4. NM_166744.3 → NP_726550.1  Crk oncogene, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726550.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RW2
      Related
      FBpp0088183
      Conserved Domains (3) summary
      cd09926
      Location:4 → 90
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
      cd11758
      Location:91 → 145
      SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
      cd11759
      Location:183 → 239
      SH3_CRK_C; C-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

    5. NM_001258482.2 → NP_001245411.1  Crk oncogene, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245411.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9XVM6
      Conserved Domains (3) summary
      cd09926
      Location:4 → 100
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
      cd11758
      Location:101 → 155
      SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
      cd11759
      Location:193 → 249
      SH3_CRK_C; C-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

    6. NM_166743.3 → NP_726549.1  Crk oncogene, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726549.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53XD2, Q9XYM0
      Related
      FBpp0088181
      Conserved Domains (3) summary
      cd09926
      Location:4 → 108
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
      cd11758
      Location:109 → 163
      SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
      cd11759
      Location:201 → 257
      SH3_CRK_C; C-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

    7. NM_001297782.1 → NP_001284711.1  Crk oncogene, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284711.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JD84
      Conserved Domains (1) summary
      cl15255
      Location:4 → 53
      SH2; Src homology 2 (SH2) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H9XVM6 H9XVM6
    H9XVM7 H9XVM7
    Q95RW2 Q95RW2
    Q9XYM0.1 Q9XYM0
    X2JCS2 X2JCS2
    X2JD84 X2JD84

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