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    CG12325 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36144, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12325provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033557
    Locus tag
    Dmel_CG12325
    See related
    AllianceGenome:FB:FBgn0033557
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12325
    Summary
    Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal small subunit assembly. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Is expressed in spermatozoon. Orthologous to human PWP2 (PWP2 small subunit processome component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12325 in Genome Data Viewer
    Location:
    47C1-47C1; 2-63 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10823405..10827644)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6710910..6715149)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ribosomal protein S15Ab Neighboring gene uncharacterized protein Neighboring gene alkaliphile Neighboring gene LTV1 ribosome biogenesis factor Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45136

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional response to dietary restriction in Drosophila melanogaster. Ding F, et al. J Insect Physiol, 2014 Oct. PMID 24819200, Free PMC Article
    2. The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. Edlich-Muth C, et al. J Mol Biol, 2015 May 22. PMID 25813344, Free PMC Article
    3. Comparative Genomic Analyses Provide New Insights into the Evolutionary Dynamics of Heterochromatin in Drosophila. Caizzi R, et al. PLoS Genet, 2016 Aug. PMID 27513559, Free PMC Article
    4. Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi. Neumüller RA, et al. Cell Stem Cell, 2011 May 6. PMID 21549331, Free PMC Article
    5. Transcription factor networks in Drosophila melanogaster. Rhee DY, et al. Cell Rep, 2014 Sep 25. PMID 25242320, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Pwp2p-containing subcomplex of 90S preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12325-PA
    CG12325-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10823405..10827644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299367.1 → NP_001286296.1  uncharacterized protein Dmel_CG12325, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286296.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U0X8
      Conserved Domains (5) summary
      COG2319
      Location:16 → 483
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:352 → 605
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam04003
      Location:794 → 893
      Utp12; Dip2/Utp12 Family
      sd00039
      Location:353 → 391
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:98 → 463
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_136774.2 → NP_610618.1  uncharacterized protein Dmel_CG12325, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610618.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U0X8
      Related
      FBpp0087322
      Conserved Domains (5) summary
      COG2319
      Location:16 → 483
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:352 → 605
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam04003
      Location:794 → 893
      Utp12; Dip2/Utp12 Family
      sd00039
      Location:353 → 391
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:98 → 463
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U0X8 Q5U0X8

    Gene LinkOut

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