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    bora aurora borealis [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40031, updated on 9-Dec-2024

    Summary

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    Official Symbol
    boraprovided by FlyBase
    Official Full Name
    aurora borealisprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259791
    Locus tag
    Dmel_CG6897
    See related
    AllianceGenome:FB:FBgn0259791
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6897; Dmel\CG6897
    Summary
    Predicted to enable protein kinase binding activity. Involved in activation of protein kinase activity and asymmetric protein localization involved in cell fate determination. Located in cytoplasm and nucleus. Is expressed in several structures, including antennal primordium; anterior endoderm; anterior endoderm anlage; head epidermis primordium; and mesoderm. Orthologous to human BORA (BORA aurora kinase A activator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bora in Genome Data Viewer
    Location:
    75D4-75D4; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18622692..18624751)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18615792..18617851)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Proline-CGG 2-3 Neighboring gene uncharacterized protein Neighboring gene non-stop Neighboring gene Myosin phosphatase targeting subunit 75D Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prolonged ovarian storage of mature Drosophila oocytes dramatically increases meiotic spindle instability. Greenblatt EJ, et al. Elife, 2019 Nov 22. PMID 31755866, Free PMC Article
    2. Identification of Genes Mediating Drosophila Follicle Cell Progenitor Differentiation by Screening for Modifiers of GAL4::UAS Variegation. Lee MC, et al. G3 (Bethesda), 2017 Jan 5. PMID 27866148, Free PMC Article
    3. Mitotic activation of the kinase Aurora-A requires its binding partner Bora. Hutterer A, et al. Dev Cell, 2006 Aug. PMID 16890155
    4. Coordinating cell polarity and cell cycle progression: what can we learn from flies and worms? Noatynska A, et al. Open Biol, 2013 Aug 7. PMID 23926048, Free PMC Article
    5. In vivo screening reveals interactions between Drosophila Manf and genes involved in the mitochondria and the ubiquinone synthesis pathway. Lindström R, et al. BMC Genet, 2017 Jun 2. PMID 28578657, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in asymmetric protein localization involved in cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aurora borealis
    Names
    CG6897-PA
    bora-PA
    borealis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18622692..18624751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140791.3 → NP_649048.1  aurora borealis [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649048.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVR2
      Related
      FBpp0074874
      Conserved Domains (1) summary
      pfam15280
      Location:60 → 258
      BORA_N; Protein aurora borealis N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVR2.1 Q9VVR2

    Gene LinkOut

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