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    GIIIspla2 Phospholipase A2 group III [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31747, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GIIIspla2provided by FlyBase
    Official Full Name
    Phospholipase A2 group IIIprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030013
    Locus tag
    Dmel_CG1583
    See related
    AllianceGenome:FB:FBgn0030013
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:HL07869; CG1583; Dmel\CG1583; Giiispla2; GIIIsPLA2
    Summary
    Predicted to enable calcium-dependent phospholipase A2 activity. Predicted to be involved in arachidonate secretion and phospholipid metabolic process. Is expressed in germline cell; organism; and primordial germ cell. Orthologous to human PLA2G3 (phospholipase A2 group III). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GIIIspla2 in Genome Data Viewer
    Location:
    7D17-7D17; 1-22 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8157628..8159348)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8051661..8053381)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene TNF-receptor-associated factor 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45536

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila. Cha GH, et al. Proc Natl Acad Sci U S A, 2005 Jul 19. PMID 16002472, Free PMC Article
    2. Drosophila spermatid individualization is sensitive to temperature and fatty acid metabolism. Ben-David G, et al. Spermatogenesis, 2015 Jan-Apr. PMID 26413411, Free PMC Article
    3. Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila. Qurashi A, et al. Hum Mol Genet, 2012 May 1. PMID 22298836, Free PMC Article
    4. Differences in Postmating Transcriptional Responses between Conspecific and Heterospecific Matings in Drosophila. Ahmed-Braimah YH, et al. Mol Biol Evol, 2021 Mar 9. PMID 33035303, Free PMC Article
    5. Systems-scale analysis reveals pathways involved in cellular response to methamphetamine. Sun L, et al. PLoS One, 2011 Apr 20. PMID 21533132, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium-dependent phospholipase A2 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phospholipase A2 group III
    Names
    CG1583-PB
    CG1583-PC
    GIIIspla2-PB
    GIIIspla2-PC
    phospholipase A[[2]]
    NP_001285008.1
    NP_572454.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8157628..8159348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298079.1 → NP_001285008.1  phospholipase A2 group III, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285008.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MR17, Q9W3I8
      Conserved Domains (1) summary
      cd04704
      Location:84 → 181
      PLA2_bee_venom_like; PLA2_bee_venom_like: A sub-family of Phospholipase A2, similar to bee venom PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the ...

    2. NM_132226.3 → NP_572454.2  phospholipase A2 group III, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572454.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MR17, Q9W3I8
      Conserved Domains (1) summary
      cd04704
      Location:84 → 181
      PLA2_bee_venom_like; PLA2_bee_venom_like: A sub-family of Phospholipase A2, similar to bee venom PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MR17 Q8MR17
    Q9W3I8 Q9W3I8

    Gene LinkOut

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