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    AIF Apoptosis inducing factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33390, updated on 27-Dec-2024

    Summary

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    Official Symbol
    AIFprovided by FlyBase
    Official Full Name
    Apoptosis inducing factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031392
    Locus tag
    Dmel_CG7263
    See related
    AllianceGenome:FB:FBgn0031392
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aif; CG7263; dAIF; DmAIF; Dmel\CG7263; SD03428p
    Summary
    Predicted to enable DNA binding activity; FAD binding activity; and NAD(P)H oxidase H2O2-forming activity. Involved in several processes, including defense response to fungus; mitochondrial ATP synthesis coupled electron transport; and mitochondrial disulfide relay system. Located in mitochondrial intermembrane space. Is expressed in adult head; adult heart; organism; and spermatozoon. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined oxidative phosphorylation deficiency 6. Orthologous to human AIFM1 (apoptosis inducing factor mitochondria associated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AIF in Genome Data Viewer
    Location:
    22D1-22D1; 2-5 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2151754..2155389)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2151754..2155389)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tubulin-binding cofactor D Neighboring gene uncharacterized protein Neighboring gene anterior open Neighboring gene long non-coding RNA:CR43751

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analyzing the integrity of oxidative phosphorylation complexes in Drosophila flight muscles. Murari A, et al. STAR Protoc, 2021 Dec 17. PMID 34977670, Free PMC Article
    2. The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function. Trotta N, et al. Curr Biol, 2004 Jul 13. PMID 15242610
    3. In vivo high-resolution magic angle spinning magnetic and electron paramagnetic resonance spectroscopic analysis of mitochondria-targeted peptide in Drosophila melanogaster with trauma-induced thoracic injury. Constantinou C, et al. Int J Mol Med, 2016 Feb. PMID 26648055, Free PMC Article
    4. The molecular archaeology of a mitochondrial death effector: AIF in Drosophila. Joza N, et al. Cell Death Differ, 2008 Jun. PMID 18309327, Free PMC Article
    5. Linking cell surface receptors to microtubules: tubulin folding cofactor D mediates Dscam functions during neuronal morphogenesis. Okumura M, et al. J Neurosci, 2015 Feb 4. PMID 25653356, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables DNA binding IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FAD binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables NAD(P)H oxidase H2O2-forming activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD(P)H oxidase H2O2-forming activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial ATP synthesis coupled electron transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial disulfide relay system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in programmed cell death involved in cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into mitochondrial intermembrane space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial intermembrane space IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    apoptosis inducing factor
    Names
    AIF-PA
    AIF-PB
    AIF-PC
    CG7263-PA
    CG7263-PB
    CG7263-PC
    NP_001259907.1
    NP_608649.2
    NP_722765.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2151754..2155389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272978.1 → NP_001259907.1  apoptosis inducing factor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259907.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH83, M9PBQ4
      Conserved Domains (3) summary
      pfam00070
      Location:426 → 511
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam07992
      Location:256 → 572
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14721
      Location:590 → 719
      AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term

    2. NM_134805.4 → NP_608649.2  apoptosis inducing factor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608649.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH83
      Related
      FBpp0077503
      Conserved Domains (3) summary
      pfam00070
      Location:362 → 447
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam07992
      Location:192 → 508
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14721
      Location:526 → 655
      AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term

    3. NM_164456.3 → NP_722765.2  apoptosis inducing factor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722765.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RIR8, Q95TL9, Q960F8, Q9VQ79
      UniProtKB/TrEMBL
      E8NH83
      Related
      FBpp0077504
      Conserved Domains (3) summary
      pfam00070
      Location:427 → 512
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam07992
      Location:257 → 573
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14721
      Location:591 → 720
      AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBQ4 M9PBQ4
    Q9VQ79.2 Q9VQ79

    Gene LinkOut

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