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    Foxc2 forkhead box C2 [ Mus musculus (house mouse) ]

    Gene ID: 14234, updated on 9-Dec-2024

    Summary

    Official Symbol
    Foxc2provided by MGI
    Official Full Name
    forkhead box C2provided by MGI
    Primary source
    MGI:MGI:1347481
    See related
    Ensembl:ENSMUSG00000046714 AllianceGenome:MGI:1347481
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mfh1; Fkh14; MFH-1; Hfhbf3
    Summary
    Enables several functions, including DNA-binding transcription activator activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Involved in several processes, including positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of vascular wound healing; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cell surface receptor signaling pathway; circulatory system development; and kidney development. Predicted to be located in nuclear body. Is expressed in several structures, including cardiovascular system; central nervous system; embryo mesenchyme; limb long bone; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including lymphedema; lymphedema-distichiasis syndrome; obesity; ptosis; and type 2 diabetes mellitus. Orthologous to human FOXC2 (forkhead box C2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Foxc2 in Genome Data Viewer
    Location:
    8 E1; 8 70.33 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (121842910..121845634)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (121116171..121118895)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene forkhead box F1 Neighboring gene methenyltetrahydrofolate synthetase domain containing Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:123632389-123632572 Neighboring gene STARR-positive B cell enhancer ABC_E9747 Neighboring gene forkhead box L1 Neighboring gene predicted gene, 33633

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (9)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA binding  
    enables DNA-binding transcription activator activity PubMed 
    enables DNA-binding transcription activator activity  
    enables DNA-binding transcription activator activity PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables chromatin DNA binding  
    enables chromatin DNA binding PubMed 
    enables identical protein binding  
    enables identical protein binding  
    enables promoter-specific chromatin binding PubMed 
    enables sequence-specific DNA binding  
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific double-stranded DNA binding  
    enables transcription cis-regulatory region binding PubMed 
    Items 1 - 25 of 61
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway PubMed 
    involved_in anatomical structure morphogenesis  
    acts_upstream_of apoptotic process involved in outflow tract morphogenesis PubMed 
    acts_upstream_of_or_within artery morphogenesis PubMed 
    acts_upstream_of_or_within blood vessel development PubMed 
    acts_upstream_of_or_within blood vessel diameter maintenance PubMed 
    acts_upstream_of_or_within blood vessel remodeling PubMed 
    acts_upstream_of_or_within branching involved in blood vessel morphogenesis PubMed 
    acts_upstream_of_or_within camera-type eye development PubMed 
    acts_upstream_of_or_within cardiac muscle cell proliferation PubMed 
    involved_in cell differentiation  
    acts_upstream_of_or_within cell population proliferation PubMed 
    acts_upstream_of_or_within collagen fibril organization PubMed 
    acts_upstream_of_or_within embryonic cranial skeleton morphogenesis PubMed 
    acts_upstream_of_or_within embryonic heart tube development PubMed 
    acts_upstream_of_or_within embryonic skeletal system morphogenesis PubMed 
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis PubMed 
    acts_upstream_of_or_within glomerular endothelium development PubMed 
    acts_upstream_of_or_within glomerular mesangial cell development PubMed 
    acts_upstream_of_or_within heart development PubMed 
    acts_upstream_of_or_within heart development PubMed 
    involved_in heart development  
    acts_upstream_of_or_within heart morphogenesis PubMed 
    involved_in insulin receptor signaling pathway  
    involved_in insulin receptor signaling pathway PubMed 
    acts_upstream_of_or_within kidney development PubMed 
    acts_upstream_of_or_within lymph vessel development PubMed 
    involved_in lymphangiogenesis  
    involved_in lymphangiogenesis PubMed 
    acts_upstream_of_or_within metanephros development PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process involved in outflow tract morphogenesis PubMed 
    involved_in negative regulation of cold-induced thermogenesis  
    involved_in negative regulation of cold-induced thermogenesis PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within neural crest cell development PubMed 
    acts_upstream_of_or_within ossification PubMed 
    acts_upstream_of_or_within paraxial mesoderm formation PubMed 
    acts_upstream_of_or_within paraxial mesodermal cell fate commitment PubMed 
    acts_upstream_of_or_within podocyte differentiation PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of cell adhesion mediated by integrin PubMed 
    involved_in positive regulation of cell migration involved in sprouting angiogenesis PubMed 
    involved_in positive regulation of endothelial cell migration PubMed 
    involved_in positive regulation of integrin activation PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of vascular wound healing PubMed 
    acts_upstream_of_or_within regulation of organ growth PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to hormone  
    involved_in response to hormone PubMed 
    acts_upstream_of_or_within skeletal system development PubMed 
    acts_upstream_of_or_within skeletal system development PubMed 
    involved_in somitogenesis PubMed 
    acts_upstream_of_or_within ureteric bud development PubMed 
    acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway PubMed 
    acts_upstream_of_or_within ventricular cardiac muscle tissue morphogenesis PubMed 
    Items 1 - 25 of 61
    Component Evidence Code Pubs
    located_in nuclear body  
    located_in nuclear body  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    forkhead box protein C2
    Names
    BF-3
    brain factor 3
    forkhead homolog 14
    forkhead-related protein FKHL14
    mesenchyme fork head protein 1
    transcription factor FKH-14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013519.2NP_038547.2  forkhead box protein C2

      See identical proteins and their annotated locations for NP_038547.2

      Status: VALIDATED

      Source sequence(s)
      AI852431, AK076319, AK146887, X92499
      Consensus CDS
      CCDS40499.1
      UniProtKB/Swiss-Prot
      P97948, Q61850, Q63869, Q8C694
      UniProtKB/TrEMBL
      B9EI61
      Related
      ENSMUSP00000055290.7, ENSMUST00000054691.8
      Conserved Domains (2) summary
      smart00339
      Location:71159
      FH; FORKHEAD
      pfam09007
      Location:167257
      EBP50_C; EBP50, C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      121842910..121845634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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