Nat8f1 N-acetyltransferase 8 (GCN5-related) family member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nat8f1provided by MGI
Official Full Name: N-acetyltransferase 8 (GCN5-related) family member 1provided by MGI
Primary source: MGI:MGI:1913366
See related: Ensembl:ENSMUSG00000057103 AllianceGenome:MGI:1913366
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cml1; 1110002I11Rik
Summary: Predicted to enable lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Predicted to be involved in several processes, including amyloid-beta metabolic process; negative regulation of apoptotic process; and peptidyl-lysine N6-acetylation. Predicted to act upstream of or within negative regulation of cell adhesion. Located in mitochondrial inner membrane. Is expressed in urinary system. Orthologous to human NAT8B (N-acetyltransferase 8B (putative, gene/pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in kidney adult (RPKM 284.1), liver adult (RPKM 210.3) and 2 other tissues See more
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Genomic context

Location:: 6 C3; 6 37.53 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (85887136..85893210, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (85910154..85915914, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces beta-secretase (BACE1) levels and Abeta generation.
Title: Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces β-secretase (BACE1) levels and Aβ generation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetyltransferase activity	NAS Non-traceable Author Statement more info	PubMed
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amyloid-beta metabolic process	ISO Inferred from Sequence Orthology more info
involved_in gastrulation with mouth forming second	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell adhesion	ISA Inferred from Sequence Alignment more info	PubMed
involved_in peptidyl-lysine N6-acetylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISA Inferred from Sequence Alignment more info	PubMed
located_in endoplasmic reticulum	ISA Inferred from Sequence Alignment more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	ISO Inferred from Sequence Orthology more info
NOT located_in extracellular space	ISA Inferred from Sequence Alignment more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in mitochondrial inner membrane	HDA more info	PubMed

General protein information

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Preferred Names: probable N-acetyltransferase CML1

Names: camello-like 1; camello-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023160.3 → NP_075649.3 probable N-acetyltransferase CML1

Status: VALIDATED

Source sequence(s)

AC158679, AC161888

Consensus CDS

CCDS20304.3

UniProtKB/Swiss-Prot

E0CYC6, Q91XE3, Q9CW77, Q9JIZ0

Related

ENSMUSP00000124488.4, ENSMUST00000161198.4

Conserved Domains (1) summary

pfam13508
Location:106 → 195

Acetyltransf_7; Acetyltransferase (GNAT) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

85887136..85893210 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506470.4 → XP_006506533.1 probable N-acetyltransferase CML1 isoform X1

See identical proteins and their annotated locations for XP_006506533.1

UniProtKB/Swiss-Prot

E0CYC6

UniProtKB/TrEMBL

E9PUL7

Conserved Domains (1) summary

pfam00583
Location:101 → 203

Acetyltransf_1; Acetyltransferase (GNAT) family