Surf4 surfeit gene 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Surf4provided by MGI
Official Full Name: surfeit gene 4provided by MGI
Primary source: MGI:MGI:98445
See related: Ensembl:ENSMUSG00000014867 AllianceGenome:MGI:98445
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Surf-4
Summary: Enables COPII receptor activity. Involved in COPII-coated vesicle cargo loading; lipid export from cell; and lipoprotein transport. Predicted to be located in Golgi apparatus; cytosol; and nuclear membrane. Predicted to be active in COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum exit site; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in embryo and pancreas tip epithelium. Orthologous to human SURF4 (surfeit 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in duodenum adult (RPKM 218.1), large intestine adult (RPKM 165.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 19.1 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (26810052..26823801, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (26920041..26933776, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion.
Title: Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion.
Surf4 (Surfeit Locus Protein 4) Deficiency Reduces Intestinal Lipid Absorption and Secretion and Decreases Metabolism in Mice.
Title: Surf4 (Surfeit Locus Protein 4) Deficiency Reduces Intestinal Lipid Absorption and Secretion and Decreases Metabolism in Mice.
Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesterol.
Title: Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesterol.
The role of hepatic Surf4 in lipoprotein metabolism and the development of atherosclerosis in apoE(-/-) mice.
Title: The role of hepatic Surf4 in lipoprotein metabolism and the development of atherosclerosis in apoE(-/-) mice.
Atherosclerosis-associated hepatic secretion of VLDL but not PCSK9 is dependent on cargo receptor protein Surf4.
Title: Atherosclerosis-associated hepatic secretion of VLDL but not PCSK9 is dependent on cargo receptor protein Surf4.
Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans.
Title: Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans.
Surf4 facilitates reprogramming by activating the cellular response to endoplasmic reticulum stress.
Title: Surf4 facilitates reprogramming by activating the cellular response to endoplasmic reticulum stress.
NIH3T3 cells overexpressing SURF4 induced tumor growth in the mice.
Title: SURF4 has oncogenic potential in NIH3T3 cells.
These findings suggest the modulatory function of Surf4 for STIM1-mediated store-operated Ca(2+) entry.
Title: Surf4 modulates STIM1-dependent calcium entry.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124243 (e-PCR)
- UniSTS:161065

Surf4 (e-PCR), detects polymorphism
- UniSTS:256407

NoName (e-PCR)
- UniSTS:224930

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables COPII receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables COPII receptor activity	ISO Inferred from Sequence Orthology more info
enables cargo receptor activity	ISO Inferred from Sequence Orthology more info
enables cargo receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in COPII-coated vesicle cargo loading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi organization	IEA Inferred from Electronic Annotation more info
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid export from cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lipid homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipoprotein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipoprotein transport	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of organelle organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of organelle organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in COPII-coated ER to Golgi transport vesicle	IEA Inferred from Electronic Annotation more info
is_active_in COPII-coated ER to Golgi transport vesicle	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum exit site	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum exit site	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum-Golgi intermediate compartment	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: surfeit locus protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001421147.1 → NP_001408076.1 surfeit locus protein 4 isoform 2

Status: VALIDATED

Source sequence(s)

AL773563

UniProtKB/TrEMBL

Q3U7E6
NM_001421148.1 → NP_001408077.1 surfeit locus protein 4 isoform 3

Status: VALIDATED

Source sequence(s)

AL773563

UniProtKB/TrEMBL

Q3U7E6
NM_011512.4 → NP_035642.1 surfeit locus protein 4 isoform 1

See identical proteins and their annotated locations for NP_035642.1

Status: VALIDATED

Source sequence(s)

AL773563

Consensus CDS

CCDS15817.1

UniProtKB/Swiss-Prot

Q64310

UniProtKB/TrEMBL

Q3U7E6, Q545Q2

Related

ENSMUSP00000015011.4, ENSMUST00000015011.10

Conserved Domains (1) summary

pfam02077
Location:4 → 269

SURF4; SURF4 family