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    Wdhd1 WD repeat and HMG-box DNA binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 218973, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdhd1provided by MGI
    Official Full Name
    WD repeat and HMG-box DNA binding protein 1provided by MGI
    Primary source
    MGI:MGI:2443514
    See related
    Ensembl:ENSMUSG00000037572 AllianceGenome:MGI:2443514
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AND-1; A630092E18; D630024B06Rik
    Summary
    Enables RNA binding activity; RNA polymerase binding activity; and chromatin binding activity. Acts upstream of or within RNA processing; pericentric heterochromatin organization; and regulation of chromosome organization. Located in chromosome, centromeric region. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system; liver; and submandibular gland primordium. Human ortholog(s) of this gene implicated in cholangiocarcinoma. Orthologous to human WDHD1 (WD repeat and HMG-box DNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E14 (RPKM 17.1), liver E14.5 (RPKM 13.7) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wdhd1 in Genome Data Viewer
    Location:
    14 C1; 14 24.6 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (47478401..47514352, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (47240944..47276861, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52169 Neighboring gene STARR-positive B cell enhancer ABC_E4106 Neighboring gene GTP cyclohydrolase 1 Neighboring gene poly(A) binding protein, cytoplasmic 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:47842732-47842946 Neighboring gene STARR-seq mESC enhancer starr_36567 Neighboring gene predicted gene, 24378 Neighboring gene suppressor of cytokine signaling 4 Neighboring gene STARR-seq mESC enhancer starr_36570 Neighboring gene mitogen-activated protein kinase 1 interacting protein 1-like Neighboring gene predicted gene, 35078

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Wdhd1 is essential for early mouse embryogenesis. Fan HH, et al. Biochim Biophys Acta Mol Cell Res, 2021 May. PMID 33716172
    2. Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis. Prakash Yadav R, et al. Reproduction, 2023 Jan 1. PMID 36194437, Free PMC Article
    3. WDHD1 modulates the post-transcriptional step of the centromeric silencing pathway. Hsieh CL, et al. Nucleic Acids Res, 2011 May. PMID 21266480, Free PMC Article
    4. CUL2(LRR1) , TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle. Villa F, et al. EMBO Rep, 2021 Mar 3. PMID 33590678, Free PMC Article
    5. Keratin 13 deficiency causes white sponge nevus in mice. Simonson L, et al. Dev Biol, 2020 Dec 1. PMID 32758484, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis.
      Title: Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis.
    2. Wdhd1 is essential for early mouse embryogenesis.
      Title: Wdhd1 is essential for early mouse embryogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within RNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pericentric heterochromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat and HMG-box DNA-binding protein 1
    Names
    acidic nucleoplasmic DNA-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360532.1 → NP_001347461.1  WD repeat and HMG-box DNA-binding protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156016, AK036390, AK052690, AK160777, BE980284, BQ748927, BY210513, CF163129
      Consensus CDS
      CCDS88642.1
      UniProtKB/Swiss-Prot
      P59328, Q6P408
      UniProtKB/TrEMBL
      A0A2K6EDP7
      Related
      ENSMUSP00000141182.3, ENSMUST00000187531.8
      Conserved Domains (5) summary
      smart00398
      Location:1006 → 1063
      HMG; high mobility group
      COG5648
      Location:949 → 1061
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd00200
      Location:10 → 289
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:21 → 54
      7WD40; WD40 repeat [structural motif]
      pfam12341
      Location:425 → 707
      Mcl1_mid; Minichromosome loss protein, Mcl1, middle region

    2. NM_172598.3 → NP_766186.2  WD repeat and HMG-box DNA-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_766186.2

      Status: VALIDATED

      Source sequence(s)
      AC156016, BC063740
      Consensus CDS
      CCDS88641.1
      UniProtKB/Swiss-Prot
      P59328, Q6P408
      UniProtKB/TrEMBL
      A0A0R4J1F8
      Related
      ENSMUSP00000107422.2, ENSMUST00000111792.9
      Conserved Domains (5) summary
      smart00398
      Location:969 → 1026
      HMG; high mobility group
      COG2319
      Location:1 → 303
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:10 → 289
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12341
      Location:388 → 670
      Mcl1_mid; Minichromosome loss protein, Mcl1, middle region
      sd00039
      Location:21 → 54
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      47478401..47514352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245012.4 → XP_011243314.1  WD repeat and HMG-box DNA-binding protein 1 isoform X1

      Related
      ENSMUSP00000107420.2, ENSMUST00000111790.2
      Conserved Domains (3) summary
      cd00200
      Location:10 → 289
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:21 → 54
      7WD40; WD40 repeat [structural motif]
      pfam12341
      Location:424 → 589
      Mcl1_mid; Minichromosome loss protein, Mcl1, middle region

    RNA

    1. XR_001781110.3 RNA Sequence

    2. XR_004938381.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59328.2 GenPept UniProtKB/Swiss-Prot:P59328

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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