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    Adss2 adenylosuccinate synthase 2 [ Mus musculus (house mouse) ]

    Gene ID: 11566, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adss2provided by MGI
    Official Full Name
    adenylosuccinate synthase 2provided by MGI
    Primary source
    MGI:MGI:87948
    See related
    Ensembl:ENSMUSG00000015961 AllianceGenome:MGI:87948
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AS; Adss; adSS 2
    Summary
    Enables adenylosuccinate synthase activity. Involved in 'de novo' AMP biosynthetic process. Acts upstream of or within AMP biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Orthologous to human ADSS2 (adenylosuccinate synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 16.5), CNS E14 (RPKM 15.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adss2 in Genome Data Viewer
    Location:
    1 H4; 1 82.81 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (177590742..177624064, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (177763176..177796695, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310043L19 gene Neighboring gene STARR-positive B cell enhancer ABC_E11111 Neighboring gene STARR-seq mESC enhancer starr_03127 Neighboring gene STARR-positive B cell enhancer ABC_E9190 Neighboring gene STARR-seq mESC enhancer starr_03128 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:179630726-179631007 Neighboring gene STARR-positive B cell enhancer ABC_E5863 Neighboring gene STARR-seq mESC enhancer starr_03129 Neighboring gene predicted gene, 30115 Neighboring gene STARR-seq mESC enhancer starr_03132 Neighboring gene STARR-seq mESC enhancer starr_03133 Neighboring gene sperm microtubule inner protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E4395 Neighboring gene STARR-positive B cell enhancer ABC_E632 Neighboring gene STARR-seq mESC enhancer starr_03135 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene cation channel sperm associated auxiliary subunit epsilon 1 Neighboring gene STARR-seq mESC enhancer starr_03137 Neighboring gene STARR-positive B cell enhancer ABC_E2589 Neighboring gene cation channel sperm associated auxiliary subunit epsilon 2 Neighboring gene predicted gene, 25312

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The purine metabolite inosine monophosphate accelerates myelopoiesis and acute pancreatitis progression. Luo XM, et al. Commun Biol, 2022 Oct 12. PMID 36224248, Free PMC Article
    2. Molecular cloning and expression of a mouse muscle cDNA encoding adenylosuccinate synthetase. Guicherit OM, et al. J Biol Chem, 1991 Nov 25. PMID 1939273
    3. Disruption of the purine nucleotide cycle by inhibition of adenylosuccinate lyase produces skeletal muscle dysfunction. Swain JL, et al. J Clin Invest, 1984 Oct. PMID 6480832, Free PMC Article
    4. Amplification of an adenylosuccinate synthetase gene in alanosine-resistant murine T-lymphoma cells. Molecular cloning of a cDNA encoding the "non-muscle" isozyme. Guicherit OM, et al. J Biol Chem, 1994 Feb 11. PMID 8308018
    5. Variations in the response of mouse isozymes of adenylosuccinate synthetase to inhibitors of physiological relevance. Borza T, et al. J Biol Chem, 2003 Feb 28. PMID 12482871

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylosuccinate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylosuccinate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylosuccinate synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' AMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' AMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' AMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in 'de novo' AMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within AMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in AMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in AMP salvage TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in IMP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in IMP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in IMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in aspartate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aspartate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to electrical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine nucleotide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to ammonium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to purine-containing compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    adenylosuccinate synthetase isozyme 2
    Names
    AMPSase 2
    IMP--aspartate ligase 2
    L-type adenylosuccinate synthetase
    adenylosuccinate synthetase 2, non muscle
    adenylosuccinate synthetase, acidic isozyme
    adenylosuccinate synthetase, liver isozyme
    adenylosuccinate synthetase, non muscle
    adenylosuccinate synthetase, non-muscle isozyme
    NP_001406878.1
    NP_001406880.1
    NP_031448.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419949.1 → NP_001406878.1  adenylosuccinate synthetase isozyme 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157787

    2. NM_001419951.1 → NP_001406880.1  adenylosuccinate synthetase isozyme 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157787

    3. NM_007422.4 → NP_031448.2  adenylosuccinate synthetase isozyme 2 isoform 1

      See identical proteins and their annotated locations for NP_031448.2

      Status: VALIDATED

      Source sequence(s)
      AC157787
      Consensus CDS
      CCDS15555.1
      UniProtKB/Swiss-Prot
      P46664, Q9CQL9
      UniProtKB/TrEMBL
      B9EIE9
      Related
      ENSMUSP00000016105.9, ENSMUST00000016105.9
      Conserved Domains (1) summary
      pfam00709
      Location:32 → 453
      Adenylsucc_synt; Adenylosuccinate synthetase

    RNA

    1. NR_185123.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157787

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      177590742..177624064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46664.2 GenPept UniProtKB/Swiss-Prot:P46664

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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