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    H2-Q10 histocompatibility 2, Q region locus 10 [ Mus musculus (house mouse) ]

    Gene ID: 15007, updated on 4-Jan-2025

    Summary

    Official Symbol
    H2-Q10provided by MGI
    Official Full Name
    histocompatibility 2, Q region locus 10provided by MGI
    Primary source
    MGI:MGI:95929
    See related
    Ensembl:ENSMUSG00000067235 AllianceGenome:MGI:95929
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Q10; Qa10; H2-K1; H-2Q10
    Summary
    Predicted to enable several functions, including 14-3-3 protein binding activity; TAP binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Located in extracellular space. Is expressed in several structures, including brain; hemolymphoid system gland; liver; reproductive system; and small intestine. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-A (major histocompatibility complex, class I, A); HLA-B (major histocompatibility complex, class I, B); and HLA-C (major histocompatibility complex, class I, C). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in liver adult (RPKM 1268.9), liver E18 (RPKM 262.7) and 3 other tissues See more
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    Genomic context

    See H2-Q10 in Genome Data Viewer
    Location:
    17 B1; 17 18.68 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35780986..35785460)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35470089..35474563)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, Q region locus 9 Neighboring gene predicted gene, 53263 Neighboring gene STARR-seq mESC enhancer starr_42453 Neighboring gene STARR-seq mESC enhancer starr_42454 Neighboring gene Pou5f1 5' regulatory region Neighboring gene predicted gene, 32362 Neighboring gene STARR-seq mESC enhancer starr_42459 Neighboring gene POU domain, class 5, transcription factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding  
    enables CD8 receptor binding  
    enables MHC class I protein binding  
    enables T cell receptor binding  
    enables TAP binding  
    enables TAP complex binding  
    enables TAP1 binding  
    enables TAP2 binding  
    enables beta-2-microglobulin binding  
    enables identical protein binding  
    enables natural killer cell lectin-like receptor binding  
    enables peptide antigen binding  
    enables peptide antigen binding  
    enables peptide binding  
    enables protein homodimerization activity  
    enables protein-containing complex binding  
    enables protein-folding chaperone binding  
    enables signaling receptor binding  
    enables signaling receptor binding  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi medial cisterna  
    located_in Golgi membrane  
    part_of MHC class I peptide loading complex  
    part_of MHC class I protein complex  
    part_of MHC class I protein complex  
    part_of MHC class Ib protein complex  
    located_in cell surface  
    located_in cis-Golgi network membrane  
    located_in early endosome  
    located_in early endosome membrane  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum exit site  
    is_active_in external side of plasma membrane  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in lumenal side of endoplasmic reticulum membrane  
    located_in lysosomal membrane  
    located_in phagocytic vesicle membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    H-2 class I histocompatibility antigen, Q10 alpha chain
    Names
    MHC class I transplantation antigen
    MHC class II antigen K

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010391.4NP_034521.1  H-2 class I histocompatibility antigen, Q10 alpha chain precursor

      See identical proteins and their annotated locations for NP_034521.1

      Status: VALIDATED

      Source sequence(s)
      CU467494
      Consensus CDS
      CCDS37599.1
      UniProtKB/Swiss-Prot
      O19475, P01898, Q31214, Q95HC3
      Related
      ENSMUSP00000066419.7, ENSMUST00000068291.7
      Conserved Domains (2) summary
      cd07698
      Location:207299
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:25203
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35780986..35785460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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