Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tab2provided by MGI
Official Full Name: TGF-beta activated kinase 1/MAP3K7 binding protein 2provided by MGI
Primary source: MGI:MGI:1915902
See related: Ensembl:ENSMUSG00000015755 AllianceGenome:MGI:1915902
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Map3k7ip2; mKIAA0733; 1110030N06Rik; A530078N03Rik
Summary: Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity; molecular adaptor activity; and zinc ion binding activity. Predicted to be involved in several processes, including non-canonical NF-kappaB signal transduction; positive regulation of canonical NF-kappaB signal transduction; and response to bacterium. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in cardiomyopathy; congenital heart disease; and ovary epithelial cancer. Orthologous to human TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 18.4), CNS E11.5 (RPKM 13.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A1; 10 2.56 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (7781412..7832039, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (7905648..7956255, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The antisense lncRNA of TAB2 that prevents oxidative stress to enhance the follicular growth in mammals.
Title: The antisense lncRNA of TAB2 that prevents oxidative stress to enhance the follicular growth in mammals.
Tripartite motif 38 alleviates the pathological process of NAFLD-NASH by promoting TAB2 degradation.
Title: Tripartite motif 38 alleviates the pathological process of NAFLD-NASH by promoting TAB2 degradation.
The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-kappaB activation and the innate immune response.
Title: The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-κB activation and the innate immune response.
TAB2 deficiency induces dilated cardiomyopathy by promoting RIPK1-dependent apoptosis and necroptosis.
Title: TAB2 deficiency induces dilated cardiomyopathy by promoting RIPK1-dependent apoptosis and necroptosis.
TET2 promotes IL-1beta expression in J774.1 cell through TLR4/MAPK signaling pathway with demethylation of TAB2 promoter.
Title: TET2 promotes IL-1β expression in J774.1 cell through TLR4/MAPK signaling pathway with demethylation of TAB2 promoter.
miR-142-3p was up-regulated both in lipopolysaccharide-induced acute lung Injury mice model and RAW264.7cells model. MiR-142a-3p mimics group experienced significant decrease in the secretion of pro-inflammatory cytokines as a result of the inhibition of NF-kappaB signaling pathway. Bioinformatics database showed that the adaptor protein, TAB2, was critical in this pathway and it is the target gene of miR-142a-3p.
Title: MiR-142a-3p alleviates Escherichia coli derived lipopolysaccharide-induced acute lung injury by targeting TAB2.
Lipopolysaccharide-induced miR-155 promoted autophagy to increase osteoclast formation via decreased TAB2.
Title: MicroRNA-155 induces autophagy in osteoclasts by targeting transforming growth factor β-activated kinase 1-binding protein 2 upon lipopolysaccharide stimulation.
These findings support a regulatory role for TGF-beta-activated kinase 1 in governing downstream MAPKs/NF-kappaB signaling cascades in the macrophage activation in response to hyperglycemic insult
Title: High glucose induced-macrophage activation through TGF-β-activated kinase 1 signaling pathway.
RNF4 negatively regulates NF-kappaB signaling by down-regulating TAB2
Title: RNF4 negatively regulates NF-κB signaling by down-regulating TAB2.
TAB1 and TAB2 are required for activated macrophages, making TAB1 and TAB2 effective targets to control inflammation by modulating macrophage survival.
Title: Activated macrophage survival is coordinated by TAK1 binding proteins.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Map3k7ip2 (e-PCR), detects polymorphism
- UniSTS:525673

STS-T59224 (e-PCR)
- UniSTS:25226

D10Mit181 (e-PCR), detects polymorphism
- UniSTS:116367

Map3k7ip2 (e-PCR), detects polymorphism
- UniSTS:507049

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables K63-linked polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Names: TGF-beta-activated kinase 1-binding protein 2; Tak1 binding protein 2; mitogen-activated protein kinase kinase kinase 7-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359534.1 → NP_001346463.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Status: VALIDATED

Source sequence(s)

AC092856, AW492243, AY093701, CN532534

Consensus CDS

CCDS23691.1

UniProtKB/Swiss-Prot

Q3UGP1, Q8BTP4, Q8CHD3, Q99K90, Q99KP4

Conserved Domains (4) summary

smart00547
Location:667 → 690

ZnF_RBZ; Zinc finger domain

cd14362
Location:9 → 50

CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins

TIGR04523
Location:537 → 614

Mplasa_alph_rch; helix-rich Mycoplasma protein

sd00029
Location:668 → 687

zf-RanBP2; RanBP2-type Zn finger [structural motif]
NM_138667.3 → NP_619608.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

See identical proteins and their annotated locations for NP_619608.1

Status: VALIDATED

Source sequence(s)

AC092856, AK003993, AY093701, BF468714, BG078791, BY429748, CK391470

Consensus CDS

CCDS23691.1

UniProtKB/Swiss-Prot

Q3UGP1, Q8BTP4, Q8CHD3, Q99K90, Q99KP4

Related

ENSMUSP00000121266.2, ENSMUST00000146444.8

Conserved Domains (4) summary

smart00547
Location:667 → 690

ZnF_RBZ; Zinc finger domain

cd14362
Location:9 → 50

CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins

TIGR04523
Location:537 → 614

Mplasa_alph_rch; helix-rich Mycoplasma protein

sd00029
Location:668 → 687

zf-RanBP2; RanBP2-type Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

7781412..7832039 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243204.4 → XP_011241506.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

See identical proteins and their annotated locations for XP_011241506.1

Conserved Domains (4) summary

smart00547
Location:693 → 716

ZnF_RBZ; Zinc finger domain

cd14362
Location:9 → 50

CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins

TIGR04523
Location:563 → 640

Mplasa_alph_rch; helix-rich Mycoplasma protein

sd00029
Location:694 → 713

zf-RanBP2; RanBP2-type Zn finger [structural motif]
XM_011243203.4 → XP_011241505.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

See identical proteins and their annotated locations for XP_011241505.1

Conserved Domains (4) summary

smart00547
Location:693 → 716

ZnF_RBZ; Zinc finger domain

cd14362
Location:9 → 50

CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins

TIGR04523
Location:563 → 640

Mplasa_alph_rch; helix-rich Mycoplasma protein

sd00029
Location:694 → 713

zf-RanBP2; RanBP2-type Zn finger [structural motif]
XM_030245247.2 → XP_030101107.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

Conserved Domains (4) summary

smart00547
Location:693 → 716

ZnF_RBZ; Zinc finger domain

cd14362
Location:9 → 50

CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins

TIGR04523
Location:563 → 640

Mplasa_alph_rch; helix-rich Mycoplasma protein

sd00029
Location:694 → 713

zf-RanBP2; RanBP2-type Zn finger [structural motif]
XM_036155973.1 → XP_036011866.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

Conserved Domains (4) summary

smart00547
Location:693 → 716

ZnF_RBZ; Zinc finger domain

cd14362
Location:9 → 50

CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins

TIGR04523
Location:563 → 640

Mplasa_alph_rch; helix-rich Mycoplasma protein

sd00029
Location:694 → 713

zf-RanBP2; RanBP2-type Zn finger [structural motif]
XM_036155974.1 → XP_036011867.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2

UniProtKB/Swiss-Prot

Q3UGP1, Q8BTP4, Q8CHD3, Q99K90, Q99KP4

Conserved Domains (4) summary

smart00547
Location:667 → 690

ZnF_RBZ; Zinc finger domain

cd14362
Location:9 → 50

CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins

TIGR04523
Location:537 → 614

Mplasa_alph_rch; helix-rich Mycoplasma protein

sd00029
Location:668 → 687

zf-RanBP2; RanBP2-type Zn finger [structural motif]
XM_036155977.1 → XP_036011870.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X4

UniProtKB/TrEMBL

D3Z216

Conserved Domains (1) summary

cd14362
Location:9 → 50

CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
XM_036155976.1 → XP_036011869.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X3

UniProtKB/TrEMBL

D3Z216

Conserved Domains (1) summary

cd14362
Location:9 → 50

CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
XM_036155975.1 → XP_036011868.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X3

UniProtKB/TrEMBL

D3Z216

Conserved Domains (1) summary

cd14362
Location:9 → 50

CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins