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    Fndc7 fibronectin type III domain containing 7 [ Mus musculus (house mouse) ]

    Gene ID: 320181, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fndc7provided by MGI
    Official Full Name
    fibronectin type III domain containing 7provided by MGI
    Primary source
    MGI:MGI:2443535
    See related
    Ensembl:ENSMUSG00000045326 AllianceGenome:MGI:2443535
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E230011A21Rik
    Summary
    Predicted to be located in extracellular region. Is expressed in adrenal gland; genitourinary system; gut; thymus; and trachea. Orthologous to human FNDC7 (fibronectin type III domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary adult (RPKM 10.0), genital fat pad adult (RPKM 1.3) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fndc7 in Genome Data Viewer
    Location:
    3 F3; 3 47.84 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108760898..108797324, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108853678..108890008, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene AKNA domain containing 1 Neighboring gene syntaxin binding protein 3 Neighboring gene STARR-positive B cell enhancer mm9_chr3:108642483-108642783 Neighboring gene STARR-positive B cell enhancer mm9_chr3:108643371-108643672 Neighboring gene STARR-positive B cell enhancer ABC_E3460 Neighboring gene STARR-positive B cell enhancer ABC_E4576 Neighboring gene PRP38 pre-mRNA processing factor 38 (yeast) domain containing B Neighboring gene HEN1 methyltransferase homolog 1 (Arabidopsis) Neighboring gene EEIG family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Homology

    Clone Names

    • MGC132926

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fibronectin type III domain-containing protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165965.1 → NP_001159437.1  fibronectin type III domain-containing protein 7 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001159437.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AK054241, AK160805, AL671894, BC111898, BG069833
      Consensus CDS
      CCDS51050.1
      UniProtKB/TrEMBL
      J3QMB8
      Related
      ENSMUSP00000051172.5, ENSMUST00000053065.8
      Conserved Domains (3) summary
      smart00060
      Location:115 → 188
      FN3; Fibronectin type 3 domain
      cd00063
      Location:289 → 369
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:28 → 96
      fn3; Fibronectin type III domain

    2. NM_177091.5 → NP_796065.2  fibronectin type III domain-containing protein 7 isoform 1 precursor

      See identical proteins and their annotated locations for NP_796065.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK053989, AK054241, AK160805, AL671894, BG069833
      Consensus CDS
      CCDS17769.1
      UniProtKB/Swiss-Prot
      A2AED1, A2AED2, A2AED3, Q14DI4, Q14DS1, Q3TNR1, Q8BW61, Q8BW83
      UniProtKB/TrEMBL
      J3QMB8
      Related
      ENSMUSP00000099680.4, ENSMUST00000102620.10
      Conserved Domains (3) summary
      smart00060
      Location:115 → 188
      FN3; Fibronectin type 3 domain
      cd00063
      Location:375 → 455
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:28 → 96
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      108760898..108797324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163132.1 → XP_036019025.1  fibronectin type III domain-containing protein 7 isoform X1

      UniProtKB/TrEMBL
      J3QMB8
      Conserved Domains (3) summary
      smart00060
      Location:115 → 188
      FN3; Fibronectin type 3 domain
      cd00063
      Location:375 → 455
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:28 → 96
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. XM_011240139.2 → XP_011238441.1  fibronectin type III domain-containing protein 7 isoform X2

      UniProtKB/TrEMBL
      J3QMB8
      Conserved Domains (3) summary
      smart00060
      Location:115 → 188
      FN3; Fibronectin type 3 domain
      cd00063
      Location:375 → 455
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:28 → 96
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AED3.1 GenPept UniProtKB/Swiss-Prot:A2AED3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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