Casp7 caspase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Casp7provided by MGI
Official Full Name: caspase 7provided by MGI
Primary source: MGI:MGI:109383
See related: Ensembl:ENSMUSG00000025076 AllianceGenome:MGI:109383
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mch3; CMH-1; mCASP-7; ICE-IAP3; caspase-7
Summary: Enables aspartic-type endopeptidase activity and cysteine-type endopeptidase activity. Involved in lymphocyte apoptotic process and protein maturation. Acts upstream of or within several processes, including execution phase of apoptosis; fibroblast apoptotic process; and neuron apoptotic process. Is active in extracellular space. Is expressed in several structures, including brain; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; colon cancer; and lung non-small cell carcinoma. Orthologous to human CASP7 (caspase 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in large intestine adult (RPKM 48.3), duodenum adult (RPKM 25.6) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 D2; 19 51.84 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (56382640..56430780)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (56396833..56442348)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Apoptotic caspase-7 activation inhibits non-canonical pyroptosis by GSDMB cleavage.
Title: Apoptotic caspase-7 activation inhibits non-canonical pyroptosis by GSDMB cleavage.
Caspase-7 activates ASM to repair gasdermin and perforin pores.
Title: Caspase-7 activates ASM to repair gasdermin and perforin pores.
Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state.
Title: Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state.
The signaling was mediated by caspase-7-induced down-regulation of the microRNA-133a (miR-133a) and consequent up-regulation of Ras homolog family member A and myosin light-chain phosphorylation.
Title: Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling.
caspase-1 regulates dopaminergic neuronal death in the pathogenesis of Parkinson's disease in mice via caspase-7/PARP1/AIF pathway.
Title: Caspase-1 Deficiency Alleviates Dopaminergic Neuronal Death via Inhibiting Caspase-7/AIF Pathway in MPTP/p Mouse Model of Parkinson's Disease.
Caspases and their substrates are key mediators of apoptosis.
Title: Organ-specific alteration in caspase expression and STK3 proteolysis during the aging process.
caspase-1 activation is an upstream event of apoptotic caspase-7 induction in renal tubulointerstitial fibrosis
Title: Role and Association of Inflammatory and Apoptotic Caspases in Renal Tubulointerstitial Fibrosis.
Cepharanthine treatment reduced mitochondrial membrane potential and upregulated the level of cleaved caspases, including caspase-9 and caspase-3/7, in a dose-dependent fashion.
Title: Cepharanthine induces apoptosis through the mitochondria/caspase pathway in murine dendritic cells.
Caspase 7 has a nonapoptic function that participates in normal spermatogenesis, but also displays apoptotic function in spermatogenic dysfunction.
Title: Apoptotic and nonapoptotic function of caspase 7 in spermatogenesis.
does not significantly contribute to cardiomyocyte death induced by transient coronary occlusion
Title: Studies on the role of apoptosis after transient myocardial ischemia: genetic deletion of the executioner caspases-3 and -7 does not limit infarct size and ventricular remodeling.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI314680 (e-PCR)
- UniSTS:160861

Casp7 (e-PCR), detects polymorphism
- UniSTS:515960

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables aspartic-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to staurosporine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to staurosporine	ISO Inferred from Sequence Orthology more info
acts_upstream_of defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in execution phase of apoptosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within execution phase of apoptosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lymphocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of positive regulation of plasma membrane repair	IDA Inferred from Direct Assay more info	PubMed
involved_in protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein processing	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	RCA inferred from Reviewed Computational Analysis more info	PubMed
acts_upstream_of_or_within response to UV	IGI Inferred from Genetic Interaction more info	PubMed
involved_in striated muscle cell differentiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: caspase-7

Names: CASP-7; apoptotic protease Mch-3; cysteine protease LICE2

NP_031637.1

EC 3.4.22.60

XP_006526679.3

EC 3.4.22.60

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007611.3 → NP_031637.1 caspase-7 precursor

See identical proteins and their annotated locations for NP_031637.1

Status: VALIDATED

Source sequence(s)

AC115771, AC166746

Consensus CDS

CCDS29915.1

UniProtKB/Swiss-Prot

O08669, P97864

UniProtKB/TrEMBL

Q4FJQ4

Related

ENSMUSP00000026062.10, ENSMUST00000026062.10

Conserved Domains (1) summary

cd00032
Location:60 → 301

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

56382640..56430780

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526616.5 → XP_006526679.3 caspase-7 isoform X1

Conserved Domains (1) summary

cd00032
Location:107 → 348

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...