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    Pde9a phosphodiesterase 9A [ Mus musculus (house mouse) ]

    Gene ID: 18585, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pde9aprovided by MGI
    Official Full Name
    phosphodiesterase 9Aprovided by MGI
    Primary source
    MGI:MGI:1277179
    See related
    Ensembl:ENSMUSG00000041119 AllianceGenome:MGI:1277179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PDE9A1
    Summary
    Enables 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cGMP catabolic process and positive regulation of cardiac muscle hypertrophy. Predicted to be located in several cellular components, including nucleoplasm; perikaryon; and sarcolemma. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human PDE9A (phosphodiesterase 9A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in colon adult (RPKM 62.7), large intestine adult (RPKM 61.1) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pde9a in Genome Data Viewer
    Location:
    17 B1; 17 16.23 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (31605079..31695284)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (31386105..31476309)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ubiquitin associated and SH3 domain containing, A Neighboring gene radial spoke head 1 homolog (Chlamydomonas) Neighboring gene STARR-seq mESC enhancer starr_42328 Neighboring gene solute carrier family 37 (glycerol-3-phosphate transporter), member 1 Neighboring gene predicted gene, 30139 Neighboring gene STARR-seq mESC enhancer starr_42332 Neighboring gene STARR-seq mESC enhancer starr_42334 Neighboring gene predicted gene 9902 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31649222-31649405 Neighboring gene STARR-positive B cell enhancer ABC_E3197 Neighboring gene WD repeat domain 4 Neighboring gene NADH:ubiquinone oxidoreductase core subunit V3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increased Energy Expenditure and Protection From Diet-Induced Obesity in Mice Lacking the cGMP-Specific Phosphodiesterase PDE9. Ceddia RP, et al. Diabetes, 2021 Dec. PMID 34620617, Free PMC Article
    2. PDE9A deficiency does not prevent chronic-hypoxic pulmonary hypertension in mice. Kolb TM, et al. Physiol Rep, 2021 Sep. PMID 34569183, Free PMC Article
    3. The effect of phosphodiesterase inhibitors on the extinction of cocaine-induced conditioned place preference in mice. Liddie S, et al. J Psychopharmacol, 2012 Oct. PMID 22596207
    4. Identification of new PDE9A isoforms and how their expression and subcellular compartmentalization in the brain change across the life span. Patel NS, et al. Neurobiol Aging, 2018 May. PMID 29505961, Free PMC Article
    5. PDE9A is expressed in the inner retina and contributes to the normal shape of the photopic ERG waveform. Dhingra A, et al. Front Mol Neurosci, 2014. PMID 25018695, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PDE9A deficiency does not prevent chronic-hypoxic pulmonary hypertension in mice.
      Title: PDE9A deficiency does not prevent chronic-hypoxic pulmonary hypertension in mice.
    2. Increased Energy Expenditure and Protection From Diet-Induced Obesity in Mice Lacking the cGMP-Specific Phosphodiesterase PDE9.
      Title: Increased Energy Expenditure and Protection From Diet-Induced Obesity in Mice Lacking the cGMP-Specific Phosphodiesterase PDE9.
    3. Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice.
      Title: Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice.
    4. Brain PDE9 is localized to preferentially regulate nuclear- and membrane-proximal pools of cGMP, and its function likely changes across the life span.
      Title: Identification of new PDE9A isoforms and how their expression and subcellular compartmentalization in the brain change across the life span.
    5. PDE9A can regulate cGMP signalling independent of the nitric oxide pathway, and its role in stress-induced heart disease suggests potential as a therapeutic target.
      Title: Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease.
    6. Data suggest that increases in hippocampal and amygdalar cGMP levels via blockade of PDE9 have prominent roles in consolidation of extinction learning (here, prevention of learning disorder due to cocaine neurotoxicity).
      Title: The effect of phosphodiesterase inhibitors on the extinction of cocaine-induced conditioned place preference in mice.
    7. This paper describes the human Pde9 gene but discusses the comparisons between the mouse and human Pde9 genes.
      Title: Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cGMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cGMP catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cGMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cGMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neural precursor cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cardiac muscle hypertrophy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcolemma ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
    NP_001157220.1
    NP_001397616.1
    NP_001397617.1
    NP_001397618.1
    NP_001397619.1
    NP_001397620.1
    NP_032830.3
    XP_036016291.1
    XP_036016292.1
    XP_036016293.1
    XP_036016294.1
    XP_036016295.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163748.2 → NP_001157220.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 1

      See identical proteins and their annotated locations for NP_001157220.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC154652, AC166172
      Consensus CDS
      CCDS28605.1
      UniProtKB/Swiss-Prot
      O70628
      UniProtKB/TrEMBL
      Q8BSU4
      Related
      ENSMUSP00000117611.2, ENSMUST00000127929.8
      Conserved Domains (1) summary
      pfam00233
      Location:250 → 478
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. NM_001410687.1 → NP_001397616.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154652, AC166172
      UniProtKB/TrEMBL
      Q8BSU4

    3. NM_001410688.1 → NP_001397617.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154652, AC166172
      UniProtKB/TrEMBL
      Q8BSU4
      Related
      ENSMUSP00000158101.2, ENSMUST00000235719.2

    4. NM_001410689.1 → NP_001397618.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC166172
      UniProtKB/TrEMBL
      A0A494BBD2, D3Z408

    5. NM_001410690.1 → NP_001397619.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC166172
      UniProtKB/TrEMBL
      A0A494BBD2, D3Z408
      Related
      ENSMUSP00000116724.3, ENSMUST00000136384.9

    6. NM_001410691.1 → NP_001397620.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154652, AC166172
      UniProtKB/TrEMBL
      A0A494BBD2, D3Z408
      Related
      ENSMUSP00000157420.2, ENSMUST00000236454.2

    7. NM_008804.5 → NP_032830.3  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 1

      See identical proteins and their annotated locations for NP_032830.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC154652, AC166172
      Consensus CDS
      CCDS28605.1
      UniProtKB/Swiss-Prot
      O70628
      UniProtKB/TrEMBL
      Q8BSU4
      Related
      ENSMUSP00000038005.6, ENSMUST00000047168.13
      Conserved Domains (1) summary
      pfam00233
      Location:250 → 478
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RNA

    1. NR_177107.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154652, AC166172

    2. NR_177108.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154652, AC166172
      Related
      ENSMUST00000124902.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      31605079..31695284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160399.1 → XP_036016292.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

      UniProtKB/TrEMBL
      A0A494BAJ0
      Related
      ENSMUSP00000158058.2, ENSMUST00000235639.2
      Conserved Domains (1) summary
      pfam00233
      Location:250 → 478
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. XM_036160398.1 → XP_036016291.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

      UniProtKB/TrEMBL
      A0A494BAJ0
      Conserved Domains (1) summary
      pfam00233
      Location:250 → 478
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. XM_036160401.1 → XP_036016294.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2

      UniProtKB/TrEMBL
      A0A494BBD2
      Conserved Domains (1) summary
      pfam00233
      Location:103 → 331
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    4. XM_036160400.1 → XP_036016293.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2

      UniProtKB/TrEMBL
      A0A494BBD2
      Conserved Domains (1) summary
      pfam00233
      Location:103 → 331
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    5. XM_036160402.1 → XP_036016295.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2

      UniProtKB/TrEMBL
      A0A494BBD2
      Conserved Domains (1) summary
      pfam00233
      Location:103 → 331
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70628.1 GenPept UniProtKB/Swiss-Prot:O70628

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