Dhx38 DEAH-box helicase 38 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dhx38provided by MGI
Official Full Name: DEAH-box helicase 38provided by MGI
Primary source: MGI:MGI:1927617
See related: Ensembl:ENSMUSG00000037993 AllianceGenome:MGI:1927617
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ddx38; Prp16; KIAA0224; 5730550P09Rik
Summary: Predicted to enable 3'-5' RNA helicase activity and RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in retinitis pigmentosa 84. Orthologous to human DHX38 (DEAH-box helicase 38). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 12.7), CNS E11.5 (RPKM 11.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 57.09 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (110274631..110292493, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (109547999..109565861, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI325984 (e-PCR)
- UniSTS:159811

AW540902 (e-PCR)
- UniSTS:179816

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5' RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

Names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 38; DEAH (Asp-Glu-Ala-His) box polypeptide 38; pre-mRNA splicing factor 16

NP_848467.1

EC 3.6.4.13

XP_006531324.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178380.2 → NP_848467.1 pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

See identical proteins and their annotated locations for NP_848467.1

Status: VALIDATED

Source sequence(s)

AC125162, AI503007, BC046557

Consensus CDS

CCDS22652.1

UniProtKB/TrEMBL

Q6A0A1, Q80X98

Related

ENSMUSP00000047865.8, ENSMUST00000042601.9

Conserved Domains (5) summary

smart00490
Location:759 → 862

HELICc; helicase superfamily c-terminal domain

smart00487
Location:527 → 714

DEXDc; DEAD-like helicases superfamily

smart00847
Location:931 → 1013

HA2; Helicase associated domain (HA2) Add an annotation

cd00046
Location:552 → 688

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam07717
Location:1064 → 1147

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RNA

NR_151644.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC125162

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

110274631..110292493 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531261.3 → XP_006531324.1 pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1

UniProtKB/TrEMBL

Q6A0A1

Conserved Domains (1) summary

COG1643
Location:515 → 1146

HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]