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    NTSR2 neurotensin receptor 2 [ Homo sapiens (human) ]

    Gene ID: 23620, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NTSR2provided by HGNC
    Official Full Name
    neurotensin receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:8040
    See related
    Ensembl:ENSG00000169006 MIM:605538; AllianceGenome:HGNC:8040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NTR2
    Summary
    The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward brain (RPKM 9.3) See more
    Orthologs
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    Genomic context

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    See NTSR2 in Genome Data Viewer
    Location:
    2p25.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (11658178..11670195, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (11691322..11703339, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (11798304..11810321, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene growth regulating estrogen receptor binding 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11714607-11715107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:11718473-11719108 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:11719109-11719744 Neighboring gene RNA, 5S ribosomal pseudogene 85 Neighboring gene Sharpr-MPRA regulatory region 7562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11175 Neighboring gene RNA, 7SL, cytoplasmic 674, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:11738736-11738940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11756351-11756851 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:11771171-11772370 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:11796533-11797486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11809762-11810298 Neighboring gene uncharacterized LOC100506405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11822031-11822671 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11828037-11828536 Neighboring gene cyclin dependent kinase 8 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11836720-11837568 Neighboring gene lipin 1 Neighboring gene uncharacterized LOC101929752

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Physiological and Pathological Roles of NTSR2 in Several Organs and Diseases (Review). Yang Y, et al. Protein Pept Lett, 2024. PMID 37962046
    2. Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells. Vita N, et al. Eur J Pharmacol, 1998 Nov 6. PMID 9851594
    3. Functional characterization of neurotensin receptors in human cutaneous T cell lymphoma malignant lymphocytes. Ramez M, et al. J Invest Dermatol, 2001 Sep. PMID 11564178
    4. Expression of neurotensin receptors in human corneal keratocytes. Bourcier T, et al. Invest Ophthalmol Vis Sci, 2002 Jun. PMID 12036977
    5. Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells. Leyton J, et al. Eur J Pharmacol, 2002 May 10. PMID 12065070

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic leukemia.
      Title: Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic leukemia.
    2. Physiological and Pathological Roles of NTSR2 in Several Organs and Diseases (Review).
      Title: Physiological and Pathological Roles of NTSR2 in Several Organs and Diseases (Review).
    3. Characterisation of the Expression of Neurotensin and Its Receptors in Human Colorectal Cancer and Its Clinical Implications.
      Title: Characterisation of the Expression of Neurotensin and Its Receptors in Human Colorectal Cancer and Its Clinical Implications.
    4. A novel role of NTS in the development of Castration-resistant prostate cancer with Neuroendocrine differentiation (NED), and a possible strategy to prevent the onset of NED by targeting the NTS signaling pathway.
      Title: Neurotensin and its receptors mediate neuroendocrine transdifferentiation in prostate cancer.
    5. High NTSR2 expression is associated with B-cell chronic lymphocytic leukemia.
      Title: Neurotensin receptor type 2 protects B-cell chronic lymphocytic leukemia cells from apoptosis.
    6. We showed that expression levels for NTS and NTSR1 varied, that NTSR2 expression was not detectable and that NTSR3 was consistently expressed in all CRC cell lines examined.
      Title: Diverse expression patterns and tumorigenic role of neurotensin signaling components in colorectal cancer cells.
    7. high expression of NTSR1 is found in clinical NETs and promoter methylation is an important mechanism controlling the differential expression of NTSR1 and silencing of NTSR2 in NET cells
      Title: Differential expression and tumorigenic function of neurotensin receptor 1 in neuroendocrine tumor cells.
    8. NTSR2 was overexpressed, NTSR1 decreased, and neurotensin was not expressed in B cell leukemia patient's B-cells, as compared with healthy B cells.
      Title: Differential expression of neurotensin and specific receptors, NTSR1 and NTSR2, in normal and malignant human B lymphocytes.
    9. this study proposes a novel function of NTR2 in the regulation of NTR1 activity.
      Title: Intermolecular cross-talk between NTR1 and NTR2 neurotensin receptor promotes intracellular sequestration and functional inhibition of NTR1 receptors.
    10. NTR2 and NTR3 were upregulated in prostate cancer cells with luminal phenotype (cytokeratin 18+)
      Title: Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled neurotensin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    neurotensin receptor type 2
    Names
    NT-R-2
    levocabastine-sensitive neurotensin receptor
    neurotensin receptor, type 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012344.4 → NP_036476.2  neurotensin receptor type 2

      Status: REVIEWED

      Source sequence(s)
      AC106875, AC110754
      Consensus CDS
      CCDS1681.1
      UniProtKB/Swiss-Prot
      O95665, Q53QQ5, Q57Z87, Q8IY58, Q8TBH6
      Related
      ENSP00000303686.5, ENST00000306928.6
      Conserved Domains (1) summary
      cd15356
      Location:33 → 369
      7tmA_NTSR2; neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      11658178..11670195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005246156.4 → XP_005246213.1  neurotensin receptor type 2 isoform X4

      Conserved Domains (1) summary
      pfam00001
      Location:98 → 182
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. XM_006711877.4 → XP_006711940.1  neurotensin receptor type 2 isoform X3

      Conserved Domains (2) summary
      cd14964
      Location:35 → 59
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:33 → 233
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_006711876.5 → XP_006711939.1  neurotensin receptor type 2 isoform X2

      Conserved Domains (1) summary
      pfam00001
      Location:98 → 234
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    4. XM_017003738.2 → XP_016859227.1  neurotensin receptor type 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      11691322..11703339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341228.1 → XP_054197203.1  neurotensin receptor type 2 isoform X4

    2. XM_054341227.1 → XP_054197202.1  neurotensin receptor type 2 isoform X3

    3. XM_054341226.1 → XP_054197201.1  neurotensin receptor type 2 isoform X2

    4. XM_054341225.1 → XP_054197200.1  neurotensin receptor type 2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95665.2 GenPept UniProtKB/Swiss-Prot:O95665

    Gene LinkOut

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