STAT3 signal transducer and activator of transcription 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STAT3provided by HGNC
Official Full Name: signal transducer and activator of transcription 3provided by HGNC
Primary source: HGNC:HGNC:11364
See related: Ensembl:ENSG00000168610 MIM:102582; AllianceGenome:HGNC:11364
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: APRF; HIES; ADMIO; ADMIO1
Summary: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression: Ubiquitous expression in gall bladder (RPKM 47.5), lung (RPKM 47.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.2

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (42313324..42388442, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (43169811..43244652, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (40465342..40540460, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA BRE-AS1 regulates the JAK2/STAT3-mediated inflammatory activation via the miR-30b-5p/SOC3 axis in THP-1 cells.
Title: LncRNA BRE-AS1 regulates the JAK2/STAT3-mediated inflammatory activation via the miR-30b-5p/SOC3 axis in THP-1 cells.
GdX inhibits the occurrence and progression of breast cancer by negatively modulating the activity of STAT3.
Title: GdX inhibits the occurrence and progression of breast cancer by negatively modulating the activity of STAT3.
STAT1 and STAT3 gain of function: clinically heterogenous immune regulatory disorders.
Title: STAT1 and STAT3 gain of function: clinically heterogenous immune regulatory disorders.
The PTPRZ1-MET/STAT3/ISG20 axis in glioma stem-like cells modulates tumor-associated macrophage polarization.
Title: The PTPRZ1-MET/STAT3/ISG20 axis in glioma stem-like cells modulates tumor-associated macrophage polarization.
The STAT3/SETDB2 axis dictates NF-kappaB-mediated inflammation in macrophages during wound repair.
Title: The STAT3/SETDB2 axis dictates NF-κB-mediated inflammation in macrophages during wound repair.
Unraveling the unphosphorylated STAT3-unphosphorylated NF-kappaB pathway in loss of function STAT3 Hyper IgE syndrome.
Title: Unraveling the unphosphorylated STAT3-unphosphorylated NF-κB pathway in loss of function STAT3 Hyper IgE syndrome.
RNAi mediated silencing of STAT3/PD-L1 in tumor-associated immune cells induces robust anti-tumor effects in immunotherapy resistant tumors.
Title: RNAi mediated silencing of STAT3/PD-L1 in tumor-associated immune cells induces robust anti-tumor effects in immunotherapy resistant tumors.
Integrated Clinical Genotype-Phenotype Characteristics of STAT3-Mutated Myeloid Neoplasms.
Title: Integrated Clinical Genotype-Phenotype Characteristics of STAT3-Mutated Myeloid Neoplasms.
Unveiling the immunoregulatory role of interferon-induced transmembrane protein 2 through the JAK/STAT3/PDL1 pathway in gastric cancer.
Title: Unveiling the immunoregulatory role of interferon-induced transmembrane protein 2 through the JAK/STAT3/PDL1 pathway in gastric cancer.
Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation via the IL-6-STAT3 axis.
Title: Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation via the IL-6-STAT3 axis.

Submit: New GeneRIF Correction See all GeneRIFs (3276)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Hyper-IgE recurrent infection syndrome 1, autosomal dominant MedGen: C2936739 OMIM: 147060 GeneReviews: STAT3 Hyper IgE Syndrome	not available
STAT3-related early-onset multisystem autoimmune disease MedGen: C4014795 OMIM: 615952 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) activates STAT3 leading to regulation of miRNA expression levels (MIR21, MIR181B1, MIR155)	PubMed
	env	HIV-1 gp120-induced release of IL-6 activates STAT3 in primary human monocyte-derived dendritic cells	PubMed
	env	HIV-1 gp120 recruits SOCS-3 through IL-10 activation for suppressing IL-6 and IL-6 dependent STAT3 in immature dentritic cells	PubMed
	env	HIV-1 gp120-induced release of IL-10 inhibits STAT3 activation, leading to suppress HIV-1 Nef-induced IL-6 secretion in immature dentritic cells	PubMed
	env	The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120	PubMed
Nef	nef	HIV-1 gp120-induced release of IL-10 inhibits STAT3 activation, leading to suppress HIV-1 Nef-induced IL-6 secretion in immature dentritic cells	PubMed
	nef	Both myristoylation and acidic cluster of Nef are essential to induce the tyrosine phosphorylation of STAT3	PubMed
	nef	HIV-1 Nef induces phosphorylation of STAT3 in M2-type macrophages	PubMed
	nef	HIV-1 Nef increases expression of both VEGF and its transcriptional regulator, hypoxia-inducible factor 2alpha (HIF-2alpha), in a Src kinase-and Stat3-dependent manner	PubMed
	nef	HIV-1 Nef activates signal transducer and activator of transcription 3 (STAT3) in the granulocyte-macrophage colony-stimulating factor-independent myeloid cell line, TF-1, and in primary human macrophages	PubMed
	nef	HIV-1 Nef specifically activates STAT3 in primary human monocyte-derived macrophages (MDM); Nef-dependent STAT3 activation is mediated by the release of soluble factor(s), including MIP-1alpha and IL-6	PubMed
	nef	HIV-1 Nef activates expression of phospho-Stat3, one of the downstream signaling pathways for cell proliferation	PubMed
	nef	HIV-1 Nef, through its PxxP and RR106 motifs, upregulates Src kinase activity and signal transducer and activator of transcription 3 (Stat3) phosphorylation, and activates the Ras-c-Raf-MAPK1,2 pathway in podocytes	PubMed
	nef	The expression of HIV-1 Nef in immature dendritic cells activates STAT3	PubMed
Tat	tat	HIV-1 Tat-induced upregulation and phosphorylation of STAT3 expression results in GFAP, Egr-1 and p300 transcription and protein expression in both Tat-expressing astrocytes and HIV-infected astrocytes	PubMed
	tat	Expression of HIV-1 Tat upregulates the abundance of signal transducer and activator of transcription 3 (STAT3) in the nucleoli of Jurkat T-cells	PubMed
	tat	HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells	PubMed
	tat	IL10 and STAT3 are required for HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells	PubMed
	tat	Ectopic expression of HIV-1 Tat induces the production of human IL-6 (huIL-6) and its receptor (huIL-6Ra) and activates STAT3 signaling; these effects are involved in Tat-mediated activation of Kaposi's sarcoma-associated herpes virus (KSHV) replication	PubMed
matrix	gag	HIV-1 MA recruits STAT3 to the LXR promoter region containing the STAT responsive sequence TTCAGGGAA; STAT3 mediates upregulation of NR1H3 (LXR-alpha) gene expression	PubMed
	gag	HIV-1 MA increases phosphorylation of STAT3	PubMed
	gag	HIV-1 MA natural variant S75X upregulates the expression of STAT1 and STAT3, and induces phosphorylation of STAT1 at position S727 and STAT3 at position Y705 in Epstein-Barr virus (EBV)-infected B-lymphocytes	PubMed
	gag	HIV-1 MA natural variant S75X-mediated proliferation of both Epstein-Barr virus (EBV)-infected primary and fully transformed B-lymphocytes requires AKT, ERK1/2, and STAT3 pathways	PubMed
	gag	Treatment of human stellate cells with HIV-1 MA induces phosphorylation of STAT1 and STAT3 proteins	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STAT3_852 (e-PCR)
- UniSTS:277773

STS-W49595 (e-PCR)
- UniSTS:50200

D8S2279 (e-PCR)
- UniSTS:473907

GDB:314949 (e-PCR)
- UniSTS:156503

D10S16 (e-PCR)
- UniSTS:155756

D15S1477 (e-PCR)
- UniSTS:474482

D1S1423 (e-PCR)
- UniSTS:149619

PMC303343P1 (e-PCR)
- UniSTS:272501

A008U14 (e-PCR)
- UniSTS:53407

PMC317074P1 (e-PCR)
- UniSTS:273070

L17809 (e-PCR)
- UniSTS:39087

NoName (e-PCR)
- UniSTS:236743

RH36906 (e-PCR)
- UniSTS:87001

RH102656 (e-PCR)
- UniSTS:96990

D3S1673 (e-PCR)
- UniSTS:148450

D17S1460E (e-PCR)
- UniSTS:150501

D5S1597E (e-PCR)
- UniSTS:151019

D4S428 (e-PCR), detects polymorphism
- UniSTS:60665

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IGI Inferred from Genetic Interaction more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	IC Inferred by Curator more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA sequestering activity	IDA Inferred from Direct Assay more info	PubMed
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lncRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables primary miRNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in T-helper 17 cell lineage commitment	ISS Inferred from Sequence or Structural Similarity more info
involved_in T-helper 17 type immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in astrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	NAS Non-traceable Author Statement more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	TAS Traceable Author Statement more info	PubMed
involved_in cell surface receptor signaling pathway via STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interleukin-17	IEA Inferred from Electronic Annotation more info
involved_in cellular response to leptin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cytokine-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
involved_in eating behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in energy homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in eye photoreceptor cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in growth hormone receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in growth hormone receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in growth hormone receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in growth hormone receptor signaling pathway via JAK-STAT	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in interleukin-10-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-11-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-15-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-2-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-23-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-6-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-6-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-9-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in leptin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in leptin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of inflammatory response to wounding	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of primary miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production involved in inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 beta production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of interleukin-10 production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-8 production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of metalloendopeptidase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of miRNA transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of vascular endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of vascular endothelial growth factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in radial glial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of feeding behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estradiol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to leptin	IDA Inferred from Direct Assay more info	PubMed
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinal rod cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in sexual reproduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in somatic stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in temperature homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase II transcription regulator complex	IC Inferred by Curator more info	PubMed
part_of RNA polymerase II transcription regulator complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
part_of RNA polymerase II transcription regulator complex	NAS Non-traceable Author Statement more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISA Inferred from Sequence Alignment more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IC Inferred by Curator more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: signal transducer and activator of transcription 3

Names: DNA-binding protein APRF; acute-phase response factor

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007370.1 RefSeqGene

Range

5001..80171

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_112

mRNA and Protein(s)

NM_001369512.1 → NP_001356441.1 signal transducer and activator of transcription 3 isoform 1

Status: REVIEWED

Source sequence(s)

AC087691, L29277

Consensus CDS

CCDS32656.1

UniProtKB/Swiss-Prot

A8K7B8, K7ENL3, O14916, P40763, Q9BW54

UniProtKB/TrEMBL

B5BTZ6

Related

ENSP00000467985.1, ENST00000588969.5

Conserved Domains (4) summary

cd10374
Location:554 → 715

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
NM_001369513.1 → NP_001356442.1 signal transducer and activator of transcription 3 isoform 1

Status: REVIEWED

Source sequence(s)

AC087691, AC107993

Consensus CDS

CCDS32656.1

UniProtKB/Swiss-Prot

A8K7B8, K7ENL3, O14916, P40763, Q9BW54

UniProtKB/TrEMBL

B5BTZ6

Related

ENSP00000503102.1, ENST00000678044.1

Conserved Domains (4) summary

cd10374
Location:554 → 715

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
NM_001369514.1 → NP_001356443.1 signal transducer and activator of transcription 3 isoform 2

Status: REVIEWED

Source sequence(s)

AC087691, AC107993

Consensus CDS

CCDS32657.1

UniProtKB/TrEMBL

B5BTZ6

Related

ENSP00000503574.1, ENST00000677723.1

Conserved Domains (4) summary

cd10374
Location:554 → 714

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
NM_001369516.1 → NP_001356445.1 signal transducer and activator of transcription 3 isoform 2

Status: REVIEWED

Source sequence(s)

AC087691, AC107993

Consensus CDS

CCDS32657.1

UniProtKB/TrEMBL

B5BTZ6

Related

ENSP00000503237.1, ENST00000679014.1

Conserved Domains (4) summary

cd10374
Location:554 → 714

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
NM_001369517.1 → NP_001356446.1 signal transducer and activator of transcription 3 isoform 3

Status: REVIEWED

Source sequence(s)

AC087691, AC107993

Consensus CDS

CCDS59288.1

UniProtKB/TrEMBL

A0A7I2V2G1

Related

ENSP00000503634.1, ENST00000678827.1

Conserved Domains (4) summary

cd10374
Location:554 → 715

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
NM_001369518.1 → NP_001356447.1 signal transducer and activator of transcription 3 isoform 3

Status: REVIEWED

Source sequence(s)

AC087691, AC107993

Consensus CDS

CCDS59288.1

UniProtKB/TrEMBL

A0A7I2V2G1

Related

ENSP00000467000.1, ENST00000585517.5

Conserved Domains (4) summary

cd10374
Location:554 → 715

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
NM_001369519.1 → NP_001356448.1 signal transducer and activator of transcription 3 isoform 4

Status: REVIEWED

Source sequence(s)

AC087691, AC107993

Consensus CDS

CCDS92313.1

UniProtKB/TrEMBL

A0A7I2V2G1, A0A7I2V395

Related

ENSP00000503559.1, ENST00000677479.1

Conserved Domains (4) summary

cd10374
Location:554 → 714

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
NM_001369520.1 → NP_001356449.1 signal transducer and activator of transcription 3 isoform 4

Status: REVIEWED

Source sequence(s)

AC087691, AC107993

Consensus CDS

CCDS92313.1

UniProtKB/TrEMBL

A0A7I2V2G1, A0A7I2V395

Related

ENSP00000503332.1, ENST00000679185.1

Conserved Domains (4) summary

cd10374
Location:554 → 714

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
NM_001384984.1 → NP_001371913.1 signal transducer and activator of transcription 3 isoform 5

Status: REVIEWED

Source sequence(s)

AC087691, AC107993

Consensus CDS

CCDS92310.1

UniProtKB/TrEMBL

A0A7I2V4C8, B5BTZ6

Related

ENSP00000503308.1, ENST00000679166.1

Conserved Domains (4) summary

cd10374
Location:526 → 687

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cl28920
Location:321 → 456

STAT_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
NM_001384985.1 → NP_001371914.1 signal transducer and activator of transcription 3 isoform 6

Status: REVIEWED

Source sequence(s)

AC087691, AC107993

UniProtKB/TrEMBL

B5BTZ6

Conserved Domains (4) summary

cd10374
Location:528 → 689

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 91

STAT_int; STAT protein, protein interaction domain

cd16853
Location:113 → 292

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:295 → 458

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
NM_001384986.1 → NP_001371915.1 signal transducer and activator of transcription 3 isoform 7

Status: REVIEWED

Source sequence(s)

AC087691, AC107993

Consensus CDS

CCDS92316.1

UniProtKB/TrEMBL

A0A7I2V5N9, A0A7I2YQD2

Related

ENSP00000503333.1, ENST00000678905.1

Conserved Domains (4) summary

cd10374
Location:559 → 719

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 489

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
NM_001384987.1 → NP_001371916.1 signal transducer and activator of transcription 3 isoform 8

Status: REVIEWED

Source sequence(s)

AC087691, AC107993

Consensus CDS

CCDS92311.1

UniProtKB/TrEMBL

A0A7I2V444, B5BTZ6

Related

ENSP00000503872.1, ENST00000678043.1

Conserved Domains (4) summary

cd10374
Location:547 → 708

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
NM_001384988.1 → NP_001371917.1 signal transducer and activator of transcription 3 isoform 9

Status: REVIEWED

Source sequence(s)

AC087691, AC107993

Consensus CDS

CCDS92312.1

UniProtKB/TrEMBL

A0A7I2V2G1, A0A7I2V4R3

Related

ENSP00000504081.1, ENST00000678535.1

Conserved Domains (4) summary

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cl15255
Location:554 → 705

SH2; Src homology 2 (SH2) domain
NM_001384989.1 → NP_001371918.1 signal transducer and activator of transcription 3 isoform 10

Status: REVIEWED

Source sequence(s)

AC087691, AC107993

Consensus CDS

CCDS92309.1

UniProtKB/TrEMBL

A0A7I2V552, B5BTZ6

Related

ENSP00000504062.1, ENST00000678674.1

Conserved Domains (4) summary

cd10374
Location:522 → 682

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16847
Location:289 → 452

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cl28921
Location:109 → 286

STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
NM_001384990.1 → NP_001371919.1 signal transducer and activator of transcription 3 isoform 11

Status: REVIEWED

Source sequence(s)

AC087691, AC107993

Consensus CDS

CCDS92315.1

UniProtKB/TrEMBL

A0A7I2V4R2, A0A7I2V5N9

Related

ENSP00000504182.1, ENST00000678572.1

Conserved Domains (4) summary

cd10374
Location:559 → 720

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 489

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
NM_001384991.1 → NP_001371920.1 signal transducer and activator of transcription 3 isoform 12

Status: REVIEWED

Source sequence(s)

AC087691, AC107993

Consensus CDS

CCDS92314.1

UniProtKB/TrEMBL

A0A7I2YQI1, A0A7I2YQR5

Related

ENSP00000504350.1, ENST00000677442.1

Conserved Domains (4) summary

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cl15255
Location:554 → 706

SH2; Src homology 2 (SH2) domain
NM_001384992.1 → NP_001371921.1 signal transducer and activator of transcription 3 isoform 13

Status: REVIEWED

Source sequence(s)

AC087691, AC107993

UniProtKB/TrEMBL

B5BTZ6

Conserved Domains (4) summary

cd10374
Location:534 → 695

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cl28920
Location:321 → 464

STAT_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
NM_001384993.1 → NP_001371922.1 signal transducer and activator of transcription 3 isoform 14

Status: REVIEWED

Source sequence(s)

AC087691, AC107993

UniProtKB/TrEMBL

A0A7I2V2G1

Conserved Domains (4) summary

cd10374
Location:554 → 715

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
NM_003150.4 → NP_003141.2 signal transducer and activator of transcription 3 isoform 2

See identical proteins and their annotated locations for NP_003141.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC087691, AI631896, AK092965, BC000627, BC008044, BI461226, CB216860, CF454565

Consensus CDS

CCDS32657.1

UniProtKB/TrEMBL

B5BTZ6

Related

ENSP00000384943.3, ENST00000404395.3

Conserved Domains (4) summary

cd10374
Location:554 → 714

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
NM_139276.3 → NP_644805.1 signal transducer and activator of transcription 3 isoform 1

See identical proteins and their annotated locations for NP_644805.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (1).

Source sequence(s)

AC087691, AI631896, AK092965, BC008044, BC014482, BI461226, CB216860, CF454565

Consensus CDS

CCDS32656.1

UniProtKB/Swiss-Prot

A8K7B8, K7ENL3, O14916, P40763, Q9BW54

UniProtKB/TrEMBL

B5BTZ6

Related

ENSP00000264657.4, ENST00000264657.10

Conserved Domains (4) summary

cd10374
Location:554 → 715

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
NM_213662.2 → NP_998827.1 signal transducer and activator of transcription 3 isoform 3

See identical proteins and their annotated locations for NP_998827.1

Status: REVIEWED

Description

Transcript Variant: This variant (3), also called STAT3B or STAT3beta, uses an alternate splice site in the 3' coding region, resulting in an early stop codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC087691, AC107993, AI631896, AK092965, BC008044, BC014482, CB216860, CB321646, CF454565

Consensus CDS

CCDS59288.1

UniProtKB/TrEMBL

A0A7I2V2G1

Related

ENSP00000503662.1, ENST00000677030.1

Conserved Domains (4) summary

cd10374
Location:554 → 715

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

42313324..42388442 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047436586.1 → XP_047292542.1 signal transducer and activator of transcription 3 isoform X3

UniProtKB/TrEMBL

B4DVR6
XM_017024973.3 → XP_016880462.1 signal transducer and activator of transcription 3 isoform X2

UniProtKB/TrEMBL

A0A7I2V2G1, A0A7I2V395

Conserved Domains (4) summary

cd10374
Location:554 → 714

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
XM_047436585.1 → XP_047292541.1 signal transducer and activator of transcription 3 isoform X1

UniProtKB/TrEMBL

A0A7I2V2G1

Related

ENSP00000373923.3, ENST00000389272.7

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

43169811..43244652 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054316993.1 → XP_054172968.1 signal transducer and activator of transcription 3 isoform X3

UniProtKB/TrEMBL

B4DVR6
XM_054316992.1 → XP_054172967.1 signal transducer and activator of transcription 3 isoform X2

UniProtKB/TrEMBL

A0A7I2V2G1, A0A7I2V395
XM_054316991.1 → XP_054172966.1 signal transducer and activator of transcription 3 isoform X1

UniProtKB/TrEMBL

A0A7I2V2G1