Ing1 inhibitor of growth family, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ing1provided by MGI
Official Full Name: inhibitor of growth family, member 1provided by MGI
Primary source: MGI:MGI:1349481
See related: Ensembl:ENSMUSG00000045969 AllianceGenome:MGI:1349481
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mING1h; p33Ing1; p37Ing1b; 2610028J21Rik
Summary: Predicted to enable methylated histone binding activity. Acts upstream of or within positive regulation of DNA-templated transcription; protein import into nucleus; and regulation of programmed cell death. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma and squamous cell carcinoma. Orthologous to human ING1 (inhibitor of growth family member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 19.0), testis adult (RPKM 15.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A1.1; 8 5.73 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (11605762..11613251)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (11555762..11563251)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ING1 knockdown leads to decreased expression of genes related to synaptic plasticity, including the regulatory subunit of calcineurin, Ppp3r1. In addition, ING1 binding at a site upstream of the transcription start site (TSS) of Ppp3r1 depends on yet another group of neuroepigenetic regulatory proteins, the Piwi-like family, which are also involved in DNA repair.
Title: A Functional Role for the Epigenetic Regulator ING1 in Activity-induced Gene Expression in Primary Cortical Neurons.
Taken together, our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration.
Title: A novel crosstalk between the tumor suppressors ING1 and ING2 regulates androgen receptor signaling.
ING1b is an important regulator of osteoblast differentiation and suppresses PPAR-beta/delta.
Title: Inhibitors of Growth 1b Suppresses Peroxisome Proliferator-Activated Receptor-β/δ Expression Through Downregulation of Hypoxia-Inducible Factor 1α in Osteoblast Differentiation.
Increased melanoma formation and dissemination in TyrNRas mice deficient in the tumor suppressor Ing1.
Title: Increased melanoma formation and dissemination in TyrNRas mice deficient in the tumor suppressor Ing1.
Study reveals a novel connection between ING1 and a regulator of microRNA biogenesis and identifies new links between tumor suppressor proteins and the microRNA machinery.
Title: Regulation of the microRNA processor DGCR8 by the tumor suppressor ING1.
Analysis of marker gene expression in p37(Ing1b)/p53 null tumors indicates that the double-null mice develop both nongerminal center and germinal center B-cell-like DLBL.
Title: p37Ing1b regulates B-cell proliferation and cooperates with p53 to suppress diffuse large B-cell lymphomagenesis.
A more sophisticated approach, using neural networks, permits prediction of interaction among three or more genes (p53, bax, and ING1).
Title: Nonlinear cooperation of p53-ING1-induced bax expression and protein S-nitrosylation in GSNO-induced thymocyte apoptosis: a quantitative approach with cross-platform validation.
important role for the Ing1 locus in protection against oncogenic stress in vivo, both as a mediator of p53 activation and as a regulator of chromatin remodeling processes.
Title: Ing1 mediates p53 accumulation and chromatin modification in response to oncogenic stress.
p37(Ing1) can negatively regulate cell growth and apoptosis in a p53-independent manner.
Title: Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis.
p33ING1 expression induces features of cellular senescence through two silencing domains and interaction with Ras
Title: Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (2) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:498267 (e-PCR)
- UniSTS:498267

Ing1 (e-PCR), detects polymorphism
- UniSTS:498267

AI875420 (e-PCR)
- UniSTS:165819

RH126501 (e-PCR)
- UniSTS:209649

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of cell migration	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Sin3-type complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: inhibitor of growth protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302451.1 → NP_001289380.1 inhibitor of growth protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an upstream alternate 5' terminal exon and uses an alternate in-frame splice site in the 5' coding region which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AA407185, AK076482, AK141466, BX528243, CJ086997

UniProtKB/TrEMBL

Q3ULE3

Conserved Domains (2) summary

cd15584
Location:176 → 220

PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)

pfam12998
Location:1 → 75

ING; Inhibitor of growth proteins N-terminal histone-binding
NM_001302457.1 → NP_001289386.1 inhibitor of growth protein 1 isoform 3

See identical proteins and their annotated locations for NP_001289386.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an upstream alternate 5' terminal exon and lacks an exon in the 5' region, which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variant 3, 4, 5 and 6 encode the same protein.

Source sequence(s)

AK076482, AK141466, AK145553, BX528243

Consensus CDS

CCDS85499.1

UniProtKB/TrEMBL

A0A1B0GT89, Q3ULE3

Related

ENSMUSP00000147476.2, ENSMUST00000210740.2

Conserved Domains (2) summary

COG5034
Location:37 → 163

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15584
Location:118 → 162

PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
NM_001302458.1 → NP_001289387.1 inhibitor of growth protein 1 isoform 3

See identical proteins and their annotated locations for NP_001289387.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an upstream alternate 5' terminal exon and lacks an exon in the 5' region, which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variant 3, 4, 5 and 6 encode the same protein.

Source sequence(s)

AC124475, AK076482, BX528243, CK624100

Consensus CDS

CCDS85499.1

UniProtKB/TrEMBL

A0A1B0GT89, Q3ULE3

Related

ENSMUSP00000148030.2, ENSMUST00000211007.2

Conserved Domains (2) summary

COG5034
Location:37 → 163

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15584
Location:118 → 162

PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
NM_001302459.1 → NP_001289388.1 inhibitor of growth protein 1 isoform 3

See identical proteins and their annotated locations for NP_001289388.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses a downstream alternate 5' terminal exon, which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variant 3, 4, 5 and 6 encode the same protein.

Source sequence(s)

AC124475, AK035490, BX528243, BY063246

Consensus CDS

CCDS85499.1

UniProtKB/TrEMBL

A0A1B0GT89, Q3ULE3

Related

ENSMUSP00000147892.2, ENSMUST00000209565.2

Conserved Domains (2) summary

COG5034
Location:37 → 163

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15584
Location:118 → 162

PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
NM_001302460.1 → NP_001289389.1 inhibitor of growth protein 1 isoform 3

See identical proteins and their annotated locations for NP_001289389.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) uses an upstream alternate 5' terminal exon and lacks an exon in the 5' region, which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variant 3, 4, 5 and 6 encode the same protein.

Source sequence(s)

AC124475, AK035490, AK141466, BX528243, CJ086997, DV655694

Consensus CDS

CCDS85499.1

UniProtKB/TrEMBL

A0A1B0GT89, Q3ULE3

Related

ENSMUSP00000148248.2, ENSMUST00000209646.2

Conserved Domains (2) summary

COG5034
Location:37 → 163

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15584
Location:118 → 162

PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
NM_011919.5 → NP_036049.2 inhibitor of growth protein 1 isoform 1

See identical proteins and their annotated locations for NP_036049.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AA407185, AC124475, AK076482, BX528243, CA320790

Consensus CDS

CCDS22097.1

UniProtKB/Swiss-Prot

B2RWH0, Q9QUP8, Q9QXV3, Q9QXV4, Q9QZX3

Related

ENSMUSP00000062593.5, ENSMUST00000054399.6

Conserved Domains (2) summary

cd15584
Location:212 → 256

PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)

pfam12998
Location:15 → 111

ING; Inhibitor of growth proteins N-terminal histone-binding