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    Zscan12 zinc finger and SCAN domain containing 12 [ Mus musculus (house mouse) ]

    Gene ID: 22758, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zscan12provided by MGI
    Official Full Name
    zinc finger and SCAN domain containing 12provided by MGI
    Primary source
    MGI:MGI:1099444
    See related
    Ensembl:ENSMUSG00000036721 AllianceGenome:MGI:1099444
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp96; FPM315; zfp-96; mKIAA0426; 2510038J07Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in central nervous system; early conceptus; genitourinary system; and thymus primordium. Orthologous to human ZSCAN12 (zinc finger and SCAN domain containing 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 3.4), testis adult (RPKM 3.3) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zscan12 in Genome Data Viewer
    Location:
    13 A3.1; 13 7.76 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (21546982..21556472)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21362820..21372302)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA methionine 13 (anticodon CAT) Neighboring gene olfactory receptor family 2 subfamily B member 28 Neighboring gene zinc finger with KRAB and SCAN domains 3 Neighboring gene STARR-seq mESC enhancer starr_33849 Neighboring gene STARR-positive B cell enhancer ABC_E10783 Neighboring gene microRNA 6942 Neighboring gene piggyBac transposable element derived 1 Neighboring gene RIKEN cDNA 4930470G03 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation of a cDNA encoding a widely expressed novel zinc finger protein with the LeR and KRAB-A domains. Yokoyama M, et al. Biochim Biophys Acta, 1997 Jul 17. PMID 9256059
    2. Three novel spermatogenesis-specific zinc finger genes. Weissig H, et al. FEBS Lett, 2003 Jul 17. PMID 12860387
    3. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cloning and characterization of its expression during spermatogenesis
      Title: Three novel spermatogenesis-specific zinc finger genes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and SCAN domain-containing protein 12
    Names
    zinc finger protein 96

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016684.3 → NP_057893.2  zinc finger and SCAN domain-containing protein 12

      See identical proteins and their annotated locations for NP_057893.2

      Status: VALIDATED

      Source sequence(s)
      BX001068
      Consensus CDS
      CCDS26273.1
      UniProtKB/Swiss-Prot
      Q8R0D8, Q9Z1D7
      Related
      ENSMUSP00000153548.2, ENSMUST00000225545.2
      Conserved Domains (4) summary
      smart00431
      Location:42 → 148
      SCAN; leucine rich region
      COG5048
      Location:231 → 437
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:446 → 466
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      21546982..21556472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247246.2 → XP_030103106.1  zinc finger and SCAN domain-containing protein 12 isoform X1

      UniProtKB/Swiss-Prot
      Q8R0D8, Q9Z1D7
      Related
      ENSMUSP00000058904.7, ENSMUST00000053293.14
      Conserved Domains (4) summary
      smart00431
      Location:42 → 148
      SCAN; leucine rich region
      COG5048
      Location:231 → 437
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:446 → 466
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006516660.3 → XP_006516723.1  zinc finger and SCAN domain-containing protein 12 isoform X1

      See identical proteins and their annotated locations for XP_006516723.1

      UniProtKB/Swiss-Prot
      Q8R0D8, Q9Z1D7
      Conserved Domains (4) summary
      smart00431
      Location:42 → 148
      SCAN; leucine rich region
      COG5048
      Location:231 → 437
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:446 → 466
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1D7.2 GenPept UniProtKB/Swiss-Prot:Q9Z1D7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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