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    Ndrg1 N-myc downstream regulated gene 1 [ Mus musculus (house mouse) ]

    Gene ID: 17988, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ndrg1provided by MGI
    Official Full Name
    N-myc downstream regulated gene 1provided by MGI
    Primary source
    MGI:MGI:1341799
    See related
    Ensembl:ENSMUSG00000005125 AllianceGenome:MGI:1341799
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RTP; DRG1; NMSL; Ndr1; Ndrl; TDD5; CAP43; CMT4D; HMSNL; PROXY1
    Summary
    Predicted to enable cadherin binding activity; small GTPase binding activity; and tubulin binding activity. Involved in negative regulation of cell population proliferation and peripheral nervous system myelin maintenance. Acts upstream of or within mast cell activation. Located in cytoplasm. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study Charcot-Marie-Tooth disease type 4D. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4D. Orthologous to human NDRG1 (N-myc downstream regulated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 707.1), liver E18 (RPKM 98.7) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ndrg1 in Genome Data Viewer
    Location:
    15 D2; 15 29.3 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (66801167..66841490, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (66929318..66969641, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46514 Neighboring gene cellular communication network factor 4 Neighboring gene predicted gene 2895 Neighboring gene STARR-seq mESC enhancer starr_38892 Neighboring gene predicted gene, 31286

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cadherin binding  
    enables cadherin binding  
    enables gamma-tubulin binding  
    enables gamma-tubulin binding  
    enables microtubule binding  
    enables microtubule binding  
    enables small GTPase binding  
    enables small GTPase binding  
    Items 1 - 20 of 21
    Component Evidence Code Pubs
    located_in adherens junction  
    located_in adherens junction  
    located_in centrosome  
    located_in centrosome  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in microtubule  
    located_in microtubule  
    located_in microtubule cytoskeleton  
    located_in myelin sheath PubMed 
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in recycling endosome membrane  
    located_in recycling endosome membrane  
    Items 1 - 20 of 21

    General protein information

    Preferred Names
    protein NDRG1
    Names
    N-myc downstream regulated 1
    N-myc downstream-regulated gene 1 protein
    protein Ndr1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008681.2NP_032707.2  protein NDRG1

      See identical proteins and their annotated locations for NP_032707.2

      Status: VALIDATED

      Source sequence(s)
      AA795988, AI118620, AK098075, AW611038, BY232155, CA320478
      Consensus CDS
      CCDS37092.1
      UniProtKB/Swiss-Prot
      P97862, Q62433
      UniProtKB/TrEMBL
      B7ZWC0, Q3TD08, Q3TSR4, Q545R3
      Related
      ENSMUSP00000005256.7, ENSMUST00000005256.14
      Conserved Domains (1) summary
      pfam03096
      Location:34316
      Ndr; Ndr family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      66801167..66841490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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