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    Hacd3 3-hydroxyacyl-CoA dehydratase 3 [ Mus musculus (house mouse) ]

    Gene ID: 57874, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hacd3provided by MGI
    Official Full Name
    3-hydroxyacyl-CoA dehydratase 3provided by MGI
    Primary source
    MGI:MGI:1889341
    See related
    Ensembl:ENSMUSG00000033629 AllianceGenome:MGI:1889341
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hcad3; B-ind1; Hspc121; Ptplad1; 4930523M17Rik
    Summary
    Predicted to enable enzyme binding activity and very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity. Involved in negative regulation of intracellular signal transduction. Acts upstream of or within JNK cascade and Rho protein signal transduction. Predicted to be located in endoplasmic reticulum and nuclear membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adrenal gland; central nervous system; gonad; retina; and tibialis anterior. Orthologous to human HACD3 (3-hydroxyacyl-CoA dehydratase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 48.9), ovary adult (RPKM 29.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hacd3 in Genome Data Viewer
    Location:
    9 C; 9 35.03 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64894265..64929014, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64986983..65021732, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 Neighboring gene predicted gene, 39361 Neighboring gene STARR-positive B cell enhancer ABC_E1789 Neighboring gene integrator complex subunit 14 Neighboring gene predicted gene, 25640 Neighboring gene STARR-positive B cell enhancer ABC_E9330 Neighboring gene predicted gene, 39362 Neighboring gene dipeptidylpeptidase 8 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. B-ind1, a novel mediator of Rac1 signaling cloned from sodium butyrate-treated fibroblasts. Courilleau D, et al. J Biol Chem, 2000 Jun 9. PMID 10747961
    2. HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth. Blondelle J, et al. J Mol Cell Biol, 2015 Oct. PMID 26160855, Free PMC Article
    3. Global gene expression analysis in fetal mouse ovaries with and without meiosis and comparison of selected genes with meiosis in the testis. Olesen C, et al. Cell Tissue Res, 2007 Apr. PMID 17431699
    4. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
    5. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC25483

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-hydroxyacyl-CoA dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation by virus of viral protein levels in host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation by virus of viral protein levels in host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of viral genome replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3
    Names
    butyrate-induced protein 1
    butyrate-induced transcript 1
    protein tyrosine phosphatase-like A domain containing 1
    protein tyrosine phosphatase-like protein PTPLAD1
    protein-tyrosine phosphatase-like A domain-containing protein 1
    very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3
    NP_067320.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021345.2 → NP_067320.2  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3

      See identical proteins and their annotated locations for NP_067320.2

      Status: VALIDATED

      Source sequence(s)
      AK159494, CJ176979, CX209453
      Consensus CDS
      CCDS23284.1
      UniProtKB/Swiss-Prot
      O09003, Q6PGH3, Q8BGM8, Q8K2C9
      Related
      ENSMUSP00000044955.6, ENSMUST00000036615.7
      Conserved Domains (2) summary
      cd06465
      Location:8 → 115
      p23_hB-ind1_like; p23_like domain found in human (h) butyrate-induced transcript 1 (B-ind1) and similar proteins. hB-ind1 participates in signaling by the small GTPase Rac1. It binds to Rac1 and enhances different Rac1 effects including activation of nuclear factor (NF) ...
      pfam04387
      Location:195 → 352
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      64894265..64929014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001778950.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2C9.2 GenPept UniProtKB/Swiss-Prot:Q8K2C9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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