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    Slc25a47 solute carrier family 25, member 47 [ Mus musculus (house mouse) ]

    Gene ID: 104910, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc25a47provided by MGI
    Official Full Name
    solute carrier family 25, member 47provided by MGI
    Primary source
    MGI:MGI:2144766
    See related
    Ensembl:ENSMUSG00000048856 AllianceGenome:MGI:2144766
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HDMCP
    Summary
    Enables NAD transmembrane transporter activity and acetyl-CoA transmembrane transporter activity. Predicted to be involved in NAD transmembrane transport and acetyl-CoA transport. Located in mitochondrial inner membrane and mitochondrial outer membrane. Is expressed in liver and metanephros. Orthologous to human SLC25A47 (solute carrier family 25 member 47). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 215.8), liver E18 (RPKM 48.5) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Slc25a47 in Genome Data Viewer
    Location:
    12 F1; 12 59.65 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (108815740..108822741)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (108849833..108856815)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7179 Neighboring gene solute carrier family 25 (mitochondrial carrier, palmitoylcarnitine transporter), member 29 Neighboring gene predicted gene, 53767 Neighboring gene microRNA 345 Neighboring gene predicted gene, 22079 Neighboring gene tryptophanyl-tRNA synthetase1 Neighboring gene STARR-positive B cell enhancer ABC_E5353 Neighboring gene STARR-seq mESC enhancer starr_33252 Neighboring gene WD repeat domain 25 Neighboring gene STARR-seq mESC enhancer starr_33253 Neighboring gene STARR-seq mESC enhancer starr_33254 Neighboring gene peptidyl prolyl isomerase H pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKα mediating lipid metabolism and tumorigenesis. Cheng L, et al. Hepatology, 2023 Dec 1. PMID 36804859, Free PMC Article
    2. Effect of miR-146 targeted HDMCP up-regulation in the pathogenesis of nonalcoholic steatohepatitis. Jin X, et al. PLoS One, 2017. PMID 28346483, Free PMC Article
    3. The SLC25A47 locus controls gluconeogenesis and energy expenditure. Yook JS, et al. Proc Natl Acad Sci U S A, 2023 Feb 28. PMID 36812201, Free PMC Article
    4. Cloning and identification of hepatocellular carcinoma down-regulated mitochondrial carrier protein, a novel liver-specific uncoupling protein. Tan MG, et al. J Biol Chem, 2004 Oct 22. PMID 15322095
    5. The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis. Bresciani N, et al. J Hepatol, 2022 Oct. PMID 35714811

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKalpha mediating lipid metabolism and tumorigenesis.
      Title: Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKα mediating lipid metabolism and tumorigenesis.
    2. The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis.
      Title: The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis.
    3. Increased HDMCP expression was identified in nonalcoholic steatohepatitis animal model and HFFA-72h cultured L02 cell. Moreover, under regulation of miR-146, nonalcoholic steatohepatitis alleviation was achieved after HDMCP downregulation in both in vivo and in vitro, according to the declination of steatosis and inflammation related markers.
      Title: Effect of miR-146 targeted HDMCP up-regulation in the pathogenesis of nonalcoholic steatohepatitis.
    4. hepatocellular carcinoma down-regulated mitochondrial carrier protein is a novel liver-specific uncoupling protein
      Title: Cloning and identification of hepatocellular carcinoma down-regulated mitochondrial carrier protein, a novel liver-specific uncoupling protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107675

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables acetyl-CoA transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in acetyl-CoA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 25 member 47
    Names
    hepatocellular carcinoma down-regulated mitochondrial carrier homolog
    mitochondrial NAD(+) transporter SLC25A47
    mitochondrial hepatocellular carcinoma-downregulated carrier protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012310.2 → NP_001012310.2  solute carrier family 25 member 47

      See identical proteins and their annotated locations for NP_001012310.2

      Status: VALIDATED

      Source sequence(s)
      AI173533, AK149369
      Consensus CDS
      CCDS26165.1
      UniProtKB/Swiss-Prot
      Q3UES2, Q5FW58, Q6IS41, Q7TPP3
      Related
      ENSMUSP00000050329.9, ENSMUST00000057026.10
      Conserved Domains (1) summary
      pfam00153
      Location:215 → 304
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      108815740..108822741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243981.4 → XP_011242283.1  solute carrier family 25 member 47 isoform X1

      Conserved Domains (1) summary
      pfam00153
      Location:226 → 307
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IS41.2 GenPept UniProtKB/Swiss-Prot:Q6IS41

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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