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    Pdzd4 PDZ domain containing 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293856, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pdzd4provided by RGD
    Official Full Name
    PDZ domain containing 4provided by RGD
    Primary source
    RGD:1561214
    See related
    EnsemblRapid:ENSRNOG00000056174 AllianceGenome:RGD:1561214
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561214
    Summary
    Orthologous to human PDZD4 (PDZ domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 54.8), Spleen (RPKM 7.3) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pdzd4 in Genome Data Viewer
    Location:
    Xq37
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (156681717..156712031, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (151530390..151560779, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (156963343..156993591)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma Neighboring gene signal sequence receptor subunit 4 Neighboring gene L1 cell adhesion molecule Neighboring gene arginine vasopressin receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    General protein information

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    Preferred Names
    PDZ domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135836.1 → NP_001129308.1  PDZ domain-containing protein 4 isoform 2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6KRU8
      Conserved Domains (1) summary
      cd00992
      Location:130 → 212
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    2. NM_001414724.1 → NP_001401653.1  PDZ domain-containing protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6KRU8, D3ZLI9
      Related
      ENSRNOP00000072313.2, ENSRNOT00000077109.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      156681717..156712031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099532.2 → XP_038955460.1  PDZ domain-containing protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZXV3, A0A8I6AJE7

    2. XM_006229565.5 → XP_006229627.1  PDZ domain-containing protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZXV3, A0A8I6AHV5
      Related
      ENSRNOP00000088024.1, ENSRNOT00000108114.2
      Conserved Domains (1) summary
      cd00992
      Location:19 → 103
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    3. XM_039099533.2 → XP_038955461.1  PDZ domain-containing protein 4 isoform X4

    4. XM_006229564.5 → XP_006229626.1  PDZ domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A6KRU8
    Nucleotide Protein Strain
    Heading Accession and Version

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