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    Ttc33 tetratricopeptide repeat domain 33 [ Mus musculus (house mouse) ]

    Gene ID: 67515, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ttc33provided by MGI
    Official Full Name
    tetratricopeptide repeat domain 33provided by MGI
    Primary source
    MGI:MGI:1914765
    See related
    Ensembl:ENSMUSG00000022151 AllianceGenome:MGI:1914765
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Osrf; 2410099M07Rik; 2900001O04Rik
    Summary
    Is expressed in central nervous system; dorsal root ganglion; and olfactory epithelium. Orthologous to human TTC33 (tetratricopeptide repeat domain 33). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 11.6), frontal lobe adult (RPKM 10.5) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ttc33 in Genome Data Viewer
    Location:
    15 A1; 15 1.99 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (5214971..5247817)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (5185490..5218336)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41256 Neighboring gene STARR-seq mESC enhancer starr_37844 Neighboring gene protein kinase, AMP-activated, alpha 1 catalytic subunit Neighboring gene predicted gene 15938 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2436 Neighboring gene prostaglandin E receptor 4 (subtype EP4) Neighboring gene STARR-seq mESC enhancer starr_37846 Neighboring gene predicted gene, 41257 Neighboring gene ribosomal protein L22 like 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
    2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 33
    Names
    TPR repeat protein 33
    osmosis responsive factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355620.1 → NP_001342549.1  tetratricopeptide repeat protein 33

      Status: VALIDATED

      Source sequence(s)
      AC135079
      Consensus CDS
      CCDS27364.1
      UniProtKB/Swiss-Prot
      Q8VIG5, Q9D6K7
      Related
      ENSMUSP00000114033.2, ENSMUST00000118193.8
      Conserved Domains (2) summary
      COG4783
      Location:42 → 164
      YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]
      sd00006
      Location:59 → 87
      TPR; TPR repeat [structural motif]

    2. NM_001355621.1 → NP_001342550.1  tetratricopeptide repeat protein 33

      Status: VALIDATED

      Source sequence(s)
      AC135079
      Consensus CDS
      CCDS27364.1
      UniProtKB/Swiss-Prot
      Q8VIG5, Q9D6K7
      Conserved Domains (2) summary
      COG4783
      Location:42 → 164
      YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]
      sd00006
      Location:59 → 87
      TPR; TPR repeat [structural motif]

    3. NM_026213.3 → NP_080489.1  tetratricopeptide repeat protein 33

      See identical proteins and their annotated locations for NP_080489.1

      Status: VALIDATED

      Source sequence(s)
      AC135079
      Consensus CDS
      CCDS27364.1
      UniProtKB/Swiss-Prot
      Q8VIG5, Q9D6K7
      Related
      ENSMUSP00000022751.9, ENSMUST00000022751.15
      Conserved Domains (2) summary
      COG4783
      Location:42 → 164
      YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]
      sd00006
      Location:59 → 87
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      5214971..5247817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248716.1 → XP_030104576.1  tetratricopeptide repeat protein 33 isoform X1

      UniProtKB/Swiss-Prot
      Q8VIG5, Q9D6K7
      Conserved Domains (2) summary
      COG4783
      Location:42 → 164
      YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]
      sd00006
      Location:59 → 87
      TPR; TPR repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D6K7.1 GenPept UniProtKB/Swiss-Prot:Q9D6K7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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