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    Tpr translocated promoter region, nuclear basket protein [ Mus musculus (house mouse) ]

    Gene ID: 108989, updated on 4-Jan-2025

    Summary

    Official Symbol
    Tprprovided by MGI
    Official Full Name
    translocated promoter region, nuclear basket proteinprovided by MGI
    Primary source
    MGI:MGI:1922066
    See related
    Ensembl:ENSMUSG00000006005 AllianceGenome:MGI:1922066
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610029M07Rik
    Summary
    Predicted to enable several functions, including dynein complex binding activity; mitogen-activated protein kinase binding activity; and protein homodimerization activity. Predicted to be a structural constituent of nuclear pore. Involved in cellular response to interferon-alpha. Located in nuclear envelope; nuclear inclusion body; and nuclear periphery. Part of nuclear pore. Is expressed in several structures, including alimentary system; brain ventricular layer; genitourinary system; olfactory epithelium; and vibrissa. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human TPR (translocated promoter region, nuclear basket protein). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 19.4), placenta adult (RPKM 13.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tpr in Genome Data Viewer
    Location:
    1 G1; 1 63.84 cM
    Exon count:
    52
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (150268544..150325686)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (150392802..150449935)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protein BEX4-like Neighboring gene STARR-seq mESC enhancer starr_02598 Neighboring gene RIKEN cDNA 2310030A07 gene Neighboring gene STARR-seq mESC enhancer starr_02599 Neighboring gene phosducin Neighboring gene STARR-positive B cell enhancer mm9_chr1:152220093-152220393 Neighboring gene STARR-positive B cell enhancer ABC_E4355 Neighboring gene STARR-positive B cell enhancer ABC_E9061 Neighboring gene odr4 GPCR localization factor homolog Neighboring gene STARR-positive B cell enhancer ABC_E2013 Neighboring gene STARR-seq mESC enhancer starr_02600 Neighboring gene STARR-seq mESC enhancer starr_02601 Neighboring gene STARR-seq mESC enhancer starr_02603 Neighboring gene proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) Neighboring gene predicted gene, 41967 Neighboring gene STARR-seq mESC enhancer starr_02604 Neighboring gene spindle and kinetochore associated complex subunit 2-like, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding  
    enables chromatin binding  
    enables dynein complex binding  
    enables dynein complex binding  
    enables heat shock protein binding  
    enables heat shock protein binding  
    enables mRNA binding  
    enables mRNA binding  
    enables mitogen-activated protein kinase binding  
    enables mitogen-activated protein kinase binding  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    NOT enables protein-membrane adaptor activity  
    enables structural constituent of nuclear pore  
    enables structural constituent of nuclear pore  
    enables structural constituent of nuclear pore  
    enables tubulin binding  
    enables tubulin binding  
    Items 1 - 25 of 48
    Process Evidence Code Pubs
    involved_in RNA export from nucleus  
    involved_in RNA export from nucleus  
    involved_in RNA import into nucleus  
    involved_in RNA import into nucleus  
    involved_in cell division  
    involved_in cellular response to heat  
    involved_in cellular response to heat  
    involved_in cellular response to interferon-alpha PubMed 
    involved_in mRNA export from nucleus  
    involved_in mRNA export from nucleus in response to heat stress  
    involved_in mRNA export from nucleus in response to heat stress  
    involved_in mitotic spindle assembly checkpoint signaling  
    involved_in mitotic spindle assembly checkpoint signaling  
    involved_in negative regulation of RNA export from nucleus  
    involved_in negative regulation of RNA export from nucleus  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of translational initiation  
    involved_in negative regulation of translational initiation  
    NOT involved_in nuclear matrix organization  
    NOT involved_in nuclear pore complex assembly  
    involved_in nuclear pore organization  
    NOT involved_in nuclear pore organization  
    involved_in nucleocytoplasmic transport PubMed 
    involved_in positive regulation of heterochromatin formation  
    involved_in positive regulation of heterochromatin formation  
    involved_in positive regulation of intracellular protein transport  
    involved_in positive regulation of intracellular protein transport  
    involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint  
    involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint  
    involved_in positive regulation of protein export from nucleus  
    involved_in positive regulation of protein export from nucleus  
    involved_in positive regulation of protein import into nucleus  
    involved_in positive regulation of protein import into nucleus  
    involved_in protein export from nucleus  
    NOT involved_in protein export from nucleus  
    involved_in protein import into nucleus  
    NOT involved_in protein import into nucleus  
    involved_in regulation of mitotic sister chromatid separation  
    involved_in regulation of mitotic sister chromatid separation  
    involved_in regulation of mitotic spindle assembly  
    involved_in regulation of mitotic spindle assembly  
    involved_in regulation of mitotic spindle assembly  
    NOT involved_in regulation of protein import into nucleus  
    involved_in regulation of protein localization  
    NOT involved_in regulation of protein stability  
    involved_in response to epidermal growth factor  
    involved_in response to epidermal growth factor  
    Items 1 - 25 of 48
    Items 1 - 20 of 26
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    part_of cytoplasmic dynein complex  
    part_of cytoplasmic dynein complex  
    located_in kinetochore  
    NOT located_in kinetochore  
    located_in mitotic spindle  
    located_in mitotic spindle  
    located_in nuclear envelope PubMed 
    located_in nuclear envelope  
    located_in nuclear inclusion body PubMed 
    located_in nuclear inclusion body  
    located_in nuclear inclusion body  
    located_in nuclear membrane  
    located_in nuclear membrane  
    located_in nuclear periphery PubMed 
    located_in nuclear periphery  
    located_in nuclear periphery  
    part_of nuclear pore  
    part_of nuclear pore PubMed 
    part_of nuclear pore  
    part_of nuclear pore  
    part_of nuclear pore PubMed 
    part_of nuclear pore nuclear basket  
    part_of nuclear pore nuclear basket  
    located_in nucleus  
    Items 1 - 20 of 26

    General protein information

    Preferred Names
    nucleoprotein TPR
    Names
    NPC-associated intranuclear protein
    nuclear pore complex-associated protein Tpr
    translocated promoter region and nuclear basket protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133780.3 → NP_598541.3  nucleoprotein TPR

      See identical proteins and their annotated locations for NP_598541.3

      Status: VALIDATED

      Source sequence(s)
      AC161432
      Consensus CDS
      CCDS35734.2
      UniProtKB/Swiss-Prot
      F6ZDS4, Q8R4A0, Q921B9
      UniProtKB/TrEMBL
      Q7M739
      Related
      ENSMUSP00000117616.3, ENSMUST00000124973.9
      Conserved Domains (6) summary
      pfam05483
      Location:363 → 1147
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      TIGR04527
      Location:1039 → 1124
      mycoplas_twoTM; two transmembrane protein
      pfam07926
      Location:1112 → 1240
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      cl12013
      Location:300 → 446
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl19219
      Location:430 → 575
      DUF342; Protein of unknown function (DUF342)
      cl23720
      Location:902 → 984
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      150268544..150325686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529065.4 → XP_006529128.1  nucleoprotein TPR isoform X1

      UniProtKB/TrEMBL
      Q7M739
      Conserved Domains (5) summary
      COG1196
      Location:127 → 870
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR00927
      Location:1897 → 2135
      2A1904; K+-dependent Na+/Ca+ exchanger
      TIGR02168
      Location:847 → 1687
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:1702 → 1936
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam07926
      Location:1110 → 1238
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
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