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    hasR heme uptake outer membrane receptor HasR [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 879855, updated on 24-Aug-2024

    Summary

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    Gene symbol
    hasR
    Gene description
    heme uptake outer membrane receptor HasR
    Locus tag
    PA3408
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (3814661..3817336, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene metalloprotease secretion protein Neighboring gene transporter HasD Neighboring gene heme acquisition protein HasA Neighboring gene transmembrane sensor Neighboring gene ECF subfamily sigma-70 factor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Contributions of the heme coordinating ligands of the Pseudomonas aeruginosa outer membrane receptor HasR to extracellular heme sensing and transport. Dent AT, et al. J Biol Chem, 2020 Jul 24. PMID 32522817, Free PMC Article
    2. Genetics and regulation of two distinct haem-uptake systems, phu and has, in Pseudomonas aeruginosa. Ochsner UA, et al. Microbiology (Reading), 2000 Jan. PMID 10658665
    3. Spectroscopic Determination of Distinct Heme Ligands in Outer-Membrane Receptors PhuR and HasR of Pseudomonas aeruginosa. Smith AD, et al. Biochemistry, 2015 Apr 28. PMID 25849630, Free PMC Article
    4. Characterization of five novel Pseudomonas aeruginosa cell-surface signalling systems. Llamas MA, et al. Mol Microbiol, 2008 Jan. PMID 18086184
    5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Contributions of the heme coordinating ligands of the Pseudomonas aeruginosa outer membrane receptor HasR to extracellular heme sensing and transport.
      Title: Contributions of the heme coordinating ligands of the Pseudomonas aeruginosa outer membrane receptor HasR to extracellular heme sensing and transport.
    2. PhuR and HasR represent nonredundant heme receptors capable of sensing and accessing heme across a wide range of physiological conditions on colonization and infection of the host.
      Title: Spectroscopic Determination of Distinct Heme Ligands in Outer-Membrane Receptors PhuR and HasR of Pseudomonas aeruginosa.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell surface receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within heme transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in outer membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heme uptake outer membrane receptor HasR
    NP_252098.1
    • Product name confidence: class 2 (High similarity to functionally studied protein)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      3814661..3817336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_252098.1 heme uptake outer membrane receptor HasR [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_252098.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q9X5P4
      Conserved Domains (2) summary
      smart00965
      Location:75 → 125
      STN; Secretin and TonB N terminus short domain
      TIGR01785
      Location:134 → 891
      TonB-hemin; TonB-dependent heme/hemoglobin receptor family protein
    Nucleotide Protein
    Heading Accession and Version

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