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    Smr domain-containing protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855902, updated on 17-Dec-2024

    Summary

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    Official Full Name
    Smr domain-containing protein
    Primary source
    SGD:S000006120
    Locus tag
    YPL199C
    See related
    AllianceGenome:SGD:S000006120; FungiDB:YPL199C; VEuPathDB:YPL199C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in nuclear-transcribed mRNA catabolic process, non-stop decay. Located in cell periphery and cytoplasm. Orthologous to human N4BP2 (NEDD4 binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (172033..172755, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Yig1p Neighboring gene Csm4p Neighboring gene ribosomal 60S subunit protein L7B Neighboring gene ncRNA Neighboring gene Oxr1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NONU-1 Encodes a Conserved Endonuclease Required for mRNA Translation Surveillance. Glover ML, et al. Cell Rep, 2020 Mar 31. PMID 32234470, Free PMC Article
    2. CSS-Palm 2.0: an updated software for palmitoylation sites prediction. Ren J, et al. Protein Eng Des Sel, 2008 Nov. PMID 18753194, Free PMC Article
    3. Protein Interactions of the Mechanosensory Proteins Wsc2 and Wsc3 for Stress Resistance in Saccharomyces cerevisiae. Vélez-Segarra V, et al. G3 (Bethesda), 2020 Sep 2. PMID 32641451, Free PMC Article
    4. Identification and Functional Testing of Novel Interacting Protein Partners for the Stress Sensors Wsc1p and Mid2p of Saccharomyces cerevisiae. Santiago-Cartagena E, et al. G3 (Bethesda), 2019 Apr 9. PMID 30733383, Free PMC Article
    5. α-Synuclein Decreases the Abundance of Proteasome Subunits and Alters Ubiquitin Conjugates in Yeast. Popova B, et al. Cells, 2021 Aug 28. PMID 34571878, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, non-stop decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Smr domain-containing protein
    NP_015125.1
    • Protein involved in nonstop mRNA decay; predicted to be palmitoylated

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      172033..172755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184013.1 → NP_015125.1  TPA: Smr domain-containing protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015125.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3H0, Q08954
      UniProtKB/TrEMBL
      A6ZW55, B3LKN0, B5VSY0, C7GN27, G2WNY5, N1NVN5
      Conserved Domains (2) summary
      smart00463
      Location:94 → 172
      SMR; Small MutS-related domain
      pfam08590
      Location:28 → 89
      DUF1771; Domain of unknown function (DUF1771)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08954.1

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