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    SEC65 RNA-binding signal recognition particle subunit SEC65 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854866, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SEC65
    Official Full Name
    RNA-binding signal recognition particle subunit SEC65
    Primary source
    SGD:S000004573
    Locus tag
    YML105C
    See related
    AllianceGenome:SGD:S000004573; FungiDB:YML105C; VEuPathDB:YML105C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 7S RNA binding activity. Involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Part of signal recognition particle, endoplasmic reticulum targeting. Orthologous to human SRP19 (signal recognition particle 19). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SEC65 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (57866..58687, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Pml39p Neighboring gene orotate phosphoribosyltransferase URA5 Neighboring gene Mdm1p Neighboring gene Nup188p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SRP samples nascent chains for the presence of signal sequences by interacting with ribosomes at a discrete step during translation elongation. Ogg SC, et al. Cell, 1995 Jun 30. PMID 7600575
    2. Mutants affecting the structure of the cortical endoplasmic reticulum in Saccharomyces cerevisiae. Prinz WA, et al. J Cell Biol, 2000 Aug 7. PMID 10931860, Free PMC Article
    3. Deletion analysis of yeast Sec65p reveals a central domain that is sufficient for function in vivo. Regnacq M, et al. Mol Microbiol, 1998 Aug. PMID 9723915
    4. Isolation and cloning of the Yarrowia lipolytica SEC65 gene, a component of the yeast signal recognition particle displaying homology with the human SRP19 gene. Sánchez M, et al. Gene, 1997 Dec 5. PMID 9426009
    5. Folding and intracellular transport of the yeast plasma-membrane H(+)-ATPase: effects of mutations in KAR2 and SEC65. Chang A, et al. Proc Natl Acad Sci U S A, 1993 Jun 15. PMID 8516333, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 7S RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 7S RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 7S RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in SRP-dependent cotranslational protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal recognition particle IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of signal recognition particle, endoplasmic reticulum targeting IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA-binding signal recognition particle subunit SEC65
    NP_013602.1
    • Subunit of the signal recognition particle (SRP); involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      57866..58687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182467.1 → NP_013602.1  TPA: RNA-binding signal recognition particle subunit SEC65 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013602.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0H9, P29478
      UniProtKB/TrEMBL
      A6ZLV9, B3LLF4, B5VP26, C7GV87, C8ZE97, G2WJV1, N1NXE7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29478.1

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