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    LTV1 Ltv1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853714, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LTV1
    Official Full Name
    Ltv1p
    Primary source
    SGD:S000001626
    Locus tag
    YKL143W
    See related
    AllianceGenome:SGD:S000001626; FungiDB:YKL143W; VEuPathDB:YKL143W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YKL2
    Summary
    Involved in several processes, including ATP export; cellular response to oxidative stress; and ribosome biogenesis. Located in late endosome membrane and nucleus. Part of Ragulator complex and preribosome, small subunit precursor. Used to study inflammatory poikiloderma with hair abnormalities and acral keratoses. Human ortholog(s) of this gene implicated in inflammatory poikiloderma with hair abnormalities and acral keratoses. Orthologous to human LTV1 (LTV1 ribosome biogenesis factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LTV1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (176781..178172)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene proteasome regulatory particle base subunit RPT1 Neighboring gene DNA-directed RNA polymerase III subunit RPC25 Neighboring gene Mrp8p Neighboring gene succinate dehydrogenase cytochrome b subunit SDH3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and biochemical interactions among Yar1, Ltv1 and Rps3 define novel links between environmental stress and ribosome biogenesis in Saccharomyces cerevisiae. Loar JW, et al. Genetics, 2004 Dec. PMID 15611164, Free PMC Article
    2. Good Vibrations: Structural Remodeling of Maturing Yeast Pre-40S Ribosomal Particles Followed by Cryo-Electron Microscopy. Shayan R, et al. Molecules, 2020 Mar 3. PMID 32138239, Free PMC Article
    3. Molecular cloning and physical analysis of an 8.2 kb segment of chromosome XI of Saccharomyces cerevisiae reveals five tightly linked genes. Abraham PR, et al. Yeast, 1992 Mar. PMID 1574929
    4. Dominant mutations in the late 40S biogenesis factor Ltv1 affect cytoplasmic maturation of the small ribosomal subunit in Saccharomyces cerevisiae. Fassio CA, et al. Genetics, 2010 May. PMID 20215468, Free PMC Article
    5. Role of the 40S beak ribosomal protein eS12 in ribosome biogenesis and function in Saccharomyces cerevisiae. Martín-Villanueva S, et al. RNA Biol, 2020 Sep. PMID 32408794, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A disease associated mutant reveals how Ltv1 orchestrates RP assembly and rRNA folding of the small ribosomal subunit head.
      Title: A disease associated mutant reveals how Ltv1 orchestrates RP assembly and rRNA folding of the small ribosomal subunit head.
    2. Ribosome biogenesis factor Ltv1 chaperones the assembly of the small subunit head.
      Title: Ribosome biogenesis factor Ltv1 chaperones the assembly of the small subunit head.
    3. nonessential role in 40S ribosomal subunit production
      Title: Genetic and biochemical interactions among Yar1, Ltv1 and Rps3 define novel links between environmental stress and ribosome biogenesis in Saccharomyces cerevisiae.
    4. Functions as one of several possible adapter proteins that link the nuclear export machinery to the small ribosomal subunit.
      Title: Ltv1 is required for efficient nuclear export of the ribosomal small subunit in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP export IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal small subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosomal small subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ragulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, small subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, small subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ltv1p
    NP_012779.1
    • Subunit of the EGO/GSE complex; the vacuolar/endosomal membrane associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest, stimulating microautophagy and sorting of Gap1p from the endosome to the plasma membrane; required for ribosomal small subunit export from nucleus; required for growth at low temperature

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      176781..178172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179709.1 → NP_012779.1  TPA: Ltv1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012779.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX53, P34078
      UniProtKB/TrEMBL
      A6ZZH8, B3LQV7, C8ZC32, G2WHP5, N1NZP6
      Conserved Domains (1) summary
      pfam04180
      Location:8 → 440
      LTV; Low temperature viability protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34078.2

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