U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    VPH2 Vph2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853741, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    VPH2
    Official Full Name
    Vph2p
    Primary source
    SGD:S000001602
    Locus tag
    YKL119C
    See related
    AllianceGenome:SGD:S000001602; FungiDB:YKL119C; VEuPathDB:YKL119C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CLS10; VMA12
    Summary
    Involved in vacuolar acidification and vacuolar proton-transporting V-type ATPase complex assembly. Located in endoplasmic reticulum membrane. Part of Vma12-Vma22 assembly complex. Used to study congenital disorder of glycosylation type IIp. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See VPH2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (218570..219217, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Dgr2p Neighboring gene Oac1p Neighboring gene tRNA-Ala Neighboring gene Hsp90 cochaperone SBA1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The VPH2 gene encodes a 25 kDa protein required for activity of the yeast vacuolar H(+)-ATPase. Bachhawat AK, et al. Yeast, 1993 Feb. PMID 8465604
    2. Sequence of a segment of yeast chromosome XI identifies a new mitochondrial carrier, a new member of the G protein family, and a protein with the PAAKK motif of the H1 histones. Colleaux L, et al. Yeast, 1992 Apr. PMID 1514329
    3. Genes required for vacuolar acidity in Saccharomyces cerevisiae. Preston RA, et al. Genetics, 1992 Jul. PMID 1628805, Free PMC Article
    4. Vma22p is a novel endoplasmic reticulum-associated protein required for assembly of the yeast vacuolar H(+)-ATPase complex. Hill KJ, et al. J Biol Chem, 1995 Sep 22. PMID 7673216
    5. VMA12 is essential for assembly of the vacuolar H(+)-ATPase subunits onto the vacuolar membrane in Saccharomyces cerevisiae. Hirata R, et al. J Biol Chem, 1993 Jan 15. PMID 8419376

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in vacuolar acidification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar proton-transporting V-type ATPase complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar proton-transporting V-type ATPase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Vma12-Vma22 assembly complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Vph2p
    NP_012803.1
    • Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase (V-ATPase) complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER); involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      218570..219217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179685.1 → NP_012803.1  TPA: Vph2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012803.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXH1, P32341
      UniProtKB/TrEMBL
      A6ZZK0, G2WHR7, N1P0S1
      Conserved Domains (1) summary
      pfam11712
      Location:64 → 196
      Vma12; Endoplasmic reticulum-based factor for assembly of V-ATPase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32341.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools