HSL1 protein kinase HSL1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HSL1
Official Full Name: protein kinase HSL1
Primary source: SGD:S000001584
Locus tag: YKL101W
See related: AllianceGenome:SGD:S000001584; FungiDB:YKL101W; VEuPathDB:YKL101W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ELM2; NIK1
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including G2/M transition of mitotic cell cycle; mitotic morphogenesis checkpoint signaling; and protein localization to septin ring. Located in cellular bud neck septin ring. Orthologous to human BRSK1 (BR serine/threonine kinase 1) and BRSK2 (BR serine/threonine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HSL1 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (248920..253476)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Growth-Dependent Activation of Protein Kinases Suggests a Mechanism for Measuring Cell Growth.
Title: Growth-Dependent Activation of Protein Kinases Suggests a Mechanism for Measuring Cell Growth.
Septin collar assembly is required for recruitment of Hsl1 to the bud neck.
Title: Coordinate action of distinct sequence elements localizes checkpoint kinase Hsl1 to the septin collar at the bud neck in Saccharomyces cerevisiae.
Hsl1p interaction with Hsl7p is not needed for degradation of septin-Swe1p fusion protein.
Title: Roles of Hsl1p and Hsl7p in Swe1p degradation: beyond septin tethering.
the "on-off" states of Nik1 affect fludioxonil sensitivity in the experimental host of S. cerevisiae
Title: Fungal fludioxonil sensitivity is diminished by a constitutively active form of the group III histidine kinase.
Cells expressing stabilized Hsl1 were sensitive to caffeine and failed to activate the Slt2 pathway.
Title: APC/CCdh1 specific degradation of Hsl1 and Clb2 is required for proper stress responses of S. cerevisiae.
Hsl1p responds to alterations in septin organization, which themselves occur in response to the local geometry of the cell cortex.
Title: Molecular dissection of the checkpoint kinase Hsl1p.
Hsl1p activation involves the phosphorylation of threonine 273, promoted by the septin-associated kinase Elm1p.
Title: The checkpoint kinase Hsl1p is activated by Elm1p-dependent phosphorylation.
Results show that survival to osmostress requires regulation of G2 progression through activation of Hog1 and phosphorylation of Hsl1.
Title: Phosphorylation of Hsl1 by Hog1 leads to a G2 arrest essential for cell survival at high osmolarity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	HDA more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic morphogenesis checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of diacylglycerol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to septin ring	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud neck	IEA Inferred from Electronic Annotation more info
located_in cellular bud neck septin ring	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud neck septin ring	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein kinase HSL1

NP_012821.2

EC 2.7.11.1

Nim1p-related protein kinase; septin-binding kinase that localizes to the bud neck septin ring and regulates the morphogenesis checkpoint; phosphorylates Hsl7p and cooperates with Elm1p to recruit Hsl7p to the mother-bud neck, as a prerequisite for the subsequent recruitment, phosphorylation, and degradation of Swe1p; phosphorylates and inhibits Pah1p, a phosphatidate phosphatase to regulate lipid synthesis; autophosphorylation enhances interactions with Hsl7p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

248920..253476

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179667.2 → NP_012821.2 TPA: protein kinase HSL1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012821.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A2NP40, D6VXI6, P34244

UniProtKB/TrEMBL

A6ZZL5, N1P7Q8

Conserved Domains (2) summary

cd14081
Location:79 → 369

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2

cl17070
Location:1347 → 1517

AMPKA_C_like; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains