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    HCA4 RNA-dependent ATPase HCA4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853419, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HCA4
    Official Full Name
    RNA-dependent ATPase HCA4
    Primary source
    SGD:S000003570
    Locus tag
    YJL033W
    See related
    AllianceGenome:SGD:S000003570; FungiDB:YJL033W; VEuPathDB:YJL033W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DBP4; ECM24
    Summary
    Enables RNA helicase activity. Involved in rRNA processing. Part of small-subunit processome. Orthologous to human DDX10 (DEAD-box helicase 10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HCA4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (383837..386149)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene tRNA(adenine34) deaminase Neighboring gene Hsp70 family ATPase KAR2 Neighboring gene Rab geranylgeranyltransferase BET4 Neighboring gene spindle checkpoint protein MAD2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Putative RNA Helicase Dbp4p Is Required for Release of the U14 snoRNA from Preribosomes in Saccharomyces cerevisiae. Kos M, et al. Mol Cell, 2005 Oct 7. PMID 16209945
    2. The rRNA-processing function of the yeast U14 small nucleolar RNA can be rescued by a conserved RNA helicase-like protein. Liang WQ, et al. Mol Cell Biol, 1997 Jul. PMID 9199348, Free PMC Article
    3. Duplex destabilization by four ribosomal DEAD-box proteins. Garcia I, et al. Biochemistry, 2012 Dec 18. PMID 23153376
    4. DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization. Popova B, et al. PLoS Genet, 2021 Mar. PMID 33657088, Free PMC Article
    5. Differential RNA-dependent ATPase activities of four rRNA processing yeast DEAD-box proteins. Garcia I, et al. Biochemistry, 2008 Nov 25. PMID 18975973, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dbp4 is required for small-subunit processome formation and function
      Title: DEAD-box RNA helicase Dbp4 is required for small-subunit processome formation and function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on RNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA-dependent ATPase HCA4
    NP_012501.1
    • DEAD box RNA helicase; component of the SSU; interacts with Bfr2p and Enp2p; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      383837..386149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181467.1 → NP_012501.1  TPA: RNA-dependent ATPase HCA4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012501.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZPU3, D6VWF0, P20448, Q6B1G2, Q92329
      UniProtKB/TrEMBL
      G2WGY5, N1NZX7
      Conserved Domains (2) summary
      COG0513
      Location:18 → 536
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd17941
      Location:52 → 249
      DEADc_DDX10; DEAD-box helicase domain of DEAD box protein 10
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20448.2

    Gene LinkOut

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