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    OST1 dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853455, updated on 9-Dec-2024

    Summary

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    Official Symbol
    OST1
    Official Full Name
    dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1
    Primary source
    SGD:S000003539
    Locus tag
    YJL002C
    See related
    AllianceGenome:SGD:S000003539; FungiDB:YJL002C; VEuPathDB:YJL002C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NLT1
    Summary
    Enables structural molecule activity. Involved in dolichol-linked oligosaccharide biosynthetic process. Located in endoplasmic reticulum. Part of oligosaccharyltransferase complex. Orthologous to human RPN1 (ribophorin I). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See OST1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (433221..434651, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Sys1p Neighboring gene Cox16p Neighboring gene proteasome core particle subunit beta 1 Neighboring gene Avt1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The essential yeast NLT1 gene encodes the 64 kDa glycoprotein subunit of the oligosaccharyl transferase. Pathak R, et al. FEBS Lett, 1995 Apr 3. PMID 7720878
    2. The Ost1p subunit of yeast oligosaccharyl transferase recognizes the peptide glycosylation site sequence, -Asn-X-Ser/Thr-. Yan Q, et al. J Biol Chem, 1999 Feb 19. PMID 9988747
    3. Studies on the function of oligosaccharyl transferase subunits: a glycosylatable photoprobe binds to the luminal domain of Ost1p. Yan Q, et al. Proc Natl Acad Sci U S A, 2002 Dec 10. PMID 12444261, Free PMC Article
    4. The alpha subunit of the Saccharomyces cerevisiae oligosaccharyltransferase complex is essential for vegetative growth of yeast and is homologous to mammalian ribophorin I. Silberstein S, et al. J Cell Biol, 1995 Feb. PMID 7860628, Free PMC Article
    5. The N-oligosaccharyltransferase complex from yeast. Knauer R, et al. FEBS Lett, 1994 May 9. PMID 8181570

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nup159 and Gle1-IP(6) regulate Dbp5 cycles by controlling its nucleotide-bound state, allowing multiple cycles of mRNP remodeling by a single Dbp5 at the nuclear pore complexes
      Title: The Dbp5 cycle at the nuclear pore complex during mRNA export II: nucleotide cycling and mRNP remodeling by Dbp5 are controlled by Nup159 and Gle1.
    2. The Dbp5-Gle1 interaction is limiting for export and, importantly, can be independent of Nup159.
      Title: The Dbp5 cycle at the nuclear pore complex during mRNA export I: dbp5 mutants with defects in RNA binding and ATP hydrolysis define key steps for Nup159 and Gle1.
    3. We report a 12 A resolution cryo-electron microscopy structure of OT from yeast.
      Title: Structure of the oligosaccharyl transferase complex at 12 A resolution.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural molecule activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dolichol-linked oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oligosaccharyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of oligosaccharyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1
    NP_012532.3
    • Alpha subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      433221..434651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181436.3 → NP_012532.3  TPA: dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012532.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWH3, P41543
      UniProtKB/TrEMBL
      A6ZPW5, C7GUU1, G2WH08, N1P3B0
      Conserved Domains (1) summary
      pfam04597
      Location:32 → 468
      Ribophorin_I; Ribophorin I
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41543.1

    Gene LinkOut

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