PAN6 pantoate--beta-alanine ligase PAN6 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PAN6
Official Full Name: pantoate--beta-alanine ligase PAN6
Primary source: SGD:S000001407
Locus tag: YIL145C
See related: AllianceGenome:SGD:S000001407; FungiDB:YIL145C; VEuPathDB:YIL145C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables pantoate-beta-alanine ligase activity. Involved in pantothenate biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PAN6 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (76354..77283, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables pantoate-beta-alanine ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pantoate-beta-alanine ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables pantoate-beta-alanine ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in pantothenate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pantothenate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in pantothenate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pantoate--beta-alanine ligase PAN6

NP_012121.2

EC 6.3.2.1

Pantothenate synthase; also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

76354..77283 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179493.1 → NP_012121.2 TPA: pantoate--beta-alanine ligase PAN6 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012121.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVE2, P40459

UniProtKB/TrEMBL

A6ZVD1, B3LTZ2, C7GUR2, C8ZAW7, G2WG07

Conserved Domains (1) summary

cl00015
Location:1 → 309

nt_trans; nucleotidyl transferase superfamily