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    AXL2 Axl2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854666, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AXL2
    Official Full Name
    Axl2p
    Primary source
    SGD:S000001402
    Locus tag
    YIL140W
    See related
    AllianceGenome:SGD:S000001402; FungiDB:YIL140W; VEuPathDB:YIL140W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BUD10; SRO4
    Summary
    Predicted to enable calcium ion binding activity. Involved in axial cellular bud site selection. Located in cellular bud neck septin ring; incipient cellular bud site; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AXL2 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (85366..87837)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene TFIIH/NER complex ATPase/helicase subunit SSL2 Neighboring gene chaperonin-containing T-complex subunit CCT2 Neighboring gene Rev7p Neighboring gene tropomyosin TPM2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cadherin-like domains in alpha-dystroglycan, alpha/epsilon-sarcoglycan and yeast and bacterial proteins. Dickens NJ, et al. Curr Biol, 2002 Mar 19. PMID 11909544
    2. Bud10p directs axial cell polarization in budding yeast and resembles a transmembrane receptor. Halme A, et al. Curr Biol, 1996 May 1. PMID 8805277
    3. Contact of cis-Golgi with ER exit sites executes cargo capture and delivery from the ER. Kurokawa K, et al. Nat Commun, 2014 Apr 14. PMID 24728174, Free PMC Article
    4. Promoter-dependent nuclear RNA degradation ensures cell cycle-specific gene expression. Catala M, et al. Commun Biol, 2019. PMID 31240249, Free PMC Article
    5. Cell cycle programs of gene expression control morphogenetic protein localization. Lord M, et al. J Cell Biol, 2000 Dec 25. PMID 11134078, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that Axl2p plays sequential and distinct roles in the regulation of cellular morphogenesis in yeast cell cycle.
      Title: Sequential and distinct roles of the cadherin domain-containing protein Axl2p in cell polarization in yeast cell cycle.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in axial cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell periphery IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck septin ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Axl2p
    NP_012126.1
    • Integral plasma membrane protein; required for axial budding in haploid cells; localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      85366..87837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179488.1 → NP_012126.1  TPA: Axl2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012126.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVE6, P38928, Q96VY8
      UniProtKB/TrEMBL
      A6ZVD5, C8ZAX3
      Conserved Domains (3) summary
      cd11303
      Location:28 → 115
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      smart00736
      Location:352 → 447
      CADG; Dystroglycan-type cadherin-like domains
      pfam08693
      Location:496 → 533
      SKG6; Transmembrane alpha-helix domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38928.1

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