GEP4 phosphatidylglycerophosphatase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GEP4
Official Full Name: phosphatidylglycerophosphatase
Primary source: SGD:S000001142
Locus tag: YHR100C
See related: AllianceGenome:SGD:S000001142; FungiDB:YHR100C; VEuPathDB:YHR100C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phosphatidylglycerophosphatase activity. Involved in cardiolipin biosynthetic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GEP4 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (314116..314673, complement)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors identify a novel phosphatase in the mitochondrial matrix space, Gep4, and demonstrate that it dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis.
Title: A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylglycerophosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylglycerophosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylglycerophosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylglycerophosphatase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables phosphatidylglycerophosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cardiolipin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiolipin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidylglycerophosphatase

NP_011968.1

EC 3.1.3.27

Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase); dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

314116..314673 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179230.1 → NP_011968.1 TPA: phosphatidylglycerophosphatase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011968.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DL50, P38812

UniProtKB/TrEMBL

A6ZT08, B3LSL5, C7GLY7, C8Z9P3, G2WFH4, N1P9E6

Conserved Domains (1) summary

pfam09419
Location:3 → 166

PGP_phosphatase; Mitochondrial PGP phosphatase