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    GPI1 phosphatidylinositol N-acetylglucosaminyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853130, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GPI1
    Official Full Name
    phosphatidylinositol N-acetylglucosaminyltransferase
    Primary source
    SGD:S000003448
    Locus tag
    YGR216C
    See related
    AllianceGenome:SGD:S000003448; FungiDB:YGR216C; VEuPathDB:YGR216C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable glycosyltransferase activity. Predicted to contribute to phosphatidylinositol N-acetylglucosaminyltransferase activity. Involved in GPI anchor biosynthetic process. Located in endoplasmic reticulum. Part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 4. Orthologous to human PIGQ (phosphatidylinositol glycan anchor biosynthesis class Q). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GPI1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (922633..924462, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S0A Neighboring gene mitochondrial 37S ribosomal protein RSM27 Neighboring gene Cch1p Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conditionally lethal yeast mutant blocked at the first step in glycosyl phosphatidylinositol anchor synthesis. Leidich SD, et al. J Biol Chem, 1994 Apr 8. PMID 8144596
    2. The GPI1 homologue from Plasmodium falciparum complements a Saccharomyces cerevisiae GPI1 anchoring mutant. Shams-Eldin H, et al. Mol Biochem Parasitol, 2002 Mar. PMID 11849707
    3. Temperature-sensitive yeast GPI anchoring mutants gpi2 and gpi3 are defective in the synthesis of N-acetylglucosaminyl phosphatidylinositol. Cloning of the GPI2 gene. Leidich SD, et al. J Biol Chem, 1995 Jun 2. PMID 7768896
    4. Gpi1, a Saccharomyces cerevisiae protein that participates in the first step in glycosylphosphatidylinositol anchor synthesis. Leidich SD, et al. J Biol Chem, 1996 Nov 1. PMID 8910381
    5. Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants. Tiede A, et al. Biochem J, 1998 Sep 15. PMID 9729469, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to phosphatidylinositol N-acetylglucosaminyltransferase activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables phosphatidylinositol N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol N-acetylglucosaminyltransferase
    NP_011732.1
    • Membrane protein involved in the synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1 are functional homologs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      922633..924462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181345.1 → NP_011732.1  TPA: phosphatidylinositol N-acetylglucosaminyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011732.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUZ9, P53306
      UniProtKB/TrEMBL
      A6ZUM7, B3LI20, C7GTX8, C8Z9A8, G2WEU5, N1P9Y5
      Conserved Domains (1) summary
      pfam05024
      Location:279 → 469
      Gpi1; N-acetylglucosaminyl transferase component (Gpi1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53306.1

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