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    TRS65 Trs65p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853076, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TRS65
    Official Full Name
    Trs65p
    Primary source
    SGD:S000003398
    Locus tag
    YGR166W
    See related
    AllianceGenome:SGD:S000003398; FungiDB:YGR166W; VEuPathDB:YGR166W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KRE11
    Summary
    Contributes to guanyl-nucleotide exchange factor activity. Involved in intra-Golgi vesicle-mediated transport and protein-containing complex assembly. Located in trans-Golgi network. Part of TRAPPII protein complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TRS65 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (830515..832197)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-Arg Neighboring gene uncharacterized protein Neighboring gene mitochondrial 37S ribosomal protein MRPS35 Neighboring gene Clc1p Neighboring gene Pex35p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PROPHECY--a yeast phenome database, update 2006. Fernandez-Ricaud L, et al. Nucleic Acids Res, 2007 Jan. PMID 17148481, Free PMC Article
    2. SKN1 and KRE6 define a pair of functional homologs encoding putative membrane proteins involved in beta-glucan synthesis. Roemer T, et al. Mol Cell Biol, 1993 Jul. PMID 8321211, Free PMC Article
    3. Conservation of the TRAPPII-specific subunits of a Ypt/Rab exchanger complex. Cox R, et al. BMC Evol Biol, 2007 Feb 2. PMID 17274825, Free PMC Article
    4. The yeast KRE9 gene encodes an O glycoprotein involved in cell surface beta-glucan assembly. Brown JL, et al. Mol Cell Biol, 1993 Oct. PMID 8413233, Free PMC Article
    5. A mutational analysis of killer toxin resistance in Saccharomyces cerevisiae identifies new genes involved in cell wall (1-->6)-beta-glucan synthesis. Brown JL, et al. Genetics, 1993 Apr. PMID 8462845, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here we demonstrate that Trs65p directly binds to the C-terminus of the Arf1p exchange factor Gea2p and provide in vivo evidence that this interaction is physiologically relevant
      Title: Trs65p, a subunit of the Ypt1p GEF TRAPPII, interacts with the Arf1p exchange factor Gea2p to facilitate COPI-mediated vesicle traffic.
    2. These results show that Trs65 plays a role in the Ypt guanine nucleotide exchanger activity of TRAPP II in concert with the two other TRAPP II-specific subunits.
      Title: The role of Trs65 in the Ypt/Rab guanine nucleotide exchange factor function of the TRAPP II complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in beta-glucan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein-containing complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TRAPPII protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPPII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TRAPPII protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Trs65p
    NP_011682.1
    • Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; role in cell wall beta-glucan biosynthesis and the stress response

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      830515..832197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181295.1 → NP_011682.1  TPA: Trs65p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011682.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUU9, P32893
      UniProtKB/TrEMBL
      A6ZUH6, B3LI65, C7GQ73, C8Z961, N1P5Z9
      Conserved Domains (1) summary
      pfam12735
      Location:257 → 559
      Trs65; TRAPP trafficking subunit Trs65
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32893.1

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