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    VMA21 Vma21p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852997, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VMA21
    Official Full Name
    Vma21p
    Primary source
    SGD:S000003337
    Locus tag
    YGR105W
    See related
    AllianceGenome:SGD:S000003337; FungiDB:YGR105W; VEuPathDB:YGR105W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in vacuolar proton-transporting V-type ATPase complex assembly. Located in endoplasmic reticulum membrane. Used to study X-linked myopathy with excessive autophagy and follicular lymphoma. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VMA21 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (698599..698832)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene mRNA-binding ribosome synthesis protein NOP7 Neighboring gene Srb5p Neighboring gene Voa1p Neighboring gene tRNA-Leu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vma21p is a yeast membrane protein retained in the endoplasmic reticulum by a di-lysine motif and is required for the assembly of the vacuolar H(+)-ATPase complex. Hill KJ, et al. Mol Biol Cell, 1994 Sep. PMID 7841520, Free PMC Article
    2. VMA12 is essential for assembly of the vacuolar H(+)-ATPase subunits onto the vacuolar membrane in Saccharomyces cerevisiae. Hirata R, et al. J Biol Chem, 1993 Jan 15. PMID 8419376
    3. Assembly of the yeast vacuolar proton-translocating ATPase. Graham LA, et al. J Bioenerg Biomembr, 1999 Feb. PMID 10340847
    4. Isolation of vacuolar membrane H(+)-ATPase-deficient yeast mutants; the VMA5 and VMA4 genes are essential for assembly and activity of the vacuolar H(+)-ATPase. Ho MN, et al. J Biol Chem, 1993 Jan 5. PMID 8416931
    5. Loss of vacuolar acidity results in iron-sulfur cluster defects and divergent homeostatic responses during aging in Saccharomyces cerevisiae. Chen KL, et al. Geroscience, 2020 Apr. PMID 31975050, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in vacuolar proton-transporting V-type ATPase complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar proton-transporting V-type ATPase complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar proton-transporting V-type ATPase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in ER to Golgi transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vma21p
    NP_011619.3
    • Integral membrane protein required for V-ATPase function; not actual component of vacuolar H+-ATPase (V-ATPase) complex; diverged ortholog of human VMA21/XMEA (X-linked Myopathy with Excessive Autophagy); functions in assembly of V-ATPase; localizes to endoplasmic reticulum (ER)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      698599..698832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181234.3 → NP_011619.3  TPA: Vma21p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011619.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZV87, B3LIC1, D6VUN7, P41806, Q6Q5Q3
      UniProtKB/TrEMBL
      C7GWV8, C8Z8Z8, G2WEJ0, N1P9W3
      Conserved Domains (1) summary
      pfam09446
      Location:9 → 61
      VMA21; VMA21-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41806.1

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